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Peer-reviewedCC BYMedicina (Kaunas, Lithuania)

Healthcare-Associated Infections with Pseudomonas spp. in a Neurosurgical Hospital: Epidemiological and Clinical Insights.

  • Nicoleta Luchian1
  • Cristian Guțu2
  • Camer Salim3
  • Alina Pleșea-Condratovici2
  • Marius Gabriel Dabija4
  • Mădălina Irina Ciuhodaru4
  • Mădălina Duceac Covrig1
  • Constantin Marcu2
  • Irina Luciana Gurzu5
  • Petruța Iuliana Moraru2
  • Mădălina Nicoleta Matei2
  • Letiția Doina Duceac2
5 affiliations
  1. 1Doctoral School of Biomedical Sciences, Faculty of Medicine and Pharmacy, "Dunărea de Jos" University of Galați, 47 Domnească Street, 800008 Galati, Romania.
  2. 2Faculty of Medicine and Pharmacy, "Dunărea de Jos" University of Galați, 47 Domnească Street, 800008 Galati, Romania.
  3. 3Faculty of Medicine, Ovidius University Constanța, 900740 Constanta, Romania.
  4. 4Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 16 Universității Street, 700115 Iasi, Romania.
  5. 5Department of Preventive Medicine and Interdisciplinarity, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 16, Universității Street, 700115 Iasi, Romania.
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Abstract

Background and Objectives: Healthcare-associated infections (HAIs) caused by Pseudomonas aeruginosa represent a challenge for healthcare systems worldwide, with significant incidence, high mortality, and increasing antibiotic resistance. This paper aims to describe and analyze the epidemiology of HAI cases with Pseudomonas aeruginosa in a tertiary neurosurgical hospital in the northeastern region of Romania during 2020-2024. Materials and Methods: Study inclusion criteria were patients of any age (as the hospital also admits pediatric patients from the region) and a diagnosis of P. aeruginosa HAI, with a signed informed consent form by the adult patient or relatives for pediatric patients. Results: During 2020-2024, 163 cases of P. aeruginosa HAIs were identified. The annual incidence decreased from 4.41‱ in 2020 to 2.37‱ in 2024 (p = 0.0038). Most cases occurred in the intensive care unit (ICU) (119/163; 73.0%), followed by neurosurgery wards (37/163; 22.7%). Overall, 110 cases (67.5%) occurred in men and 53 (32.5%) in women. The analysis also showed a predominance of late-onset cases and the presence of antimicrobial-resistant phenotypes among the identified P. aeruginosa isolates. Conclusions: This study provides an integrated epidemiological characterization of P. aeruginosa HAIs in a regional neurosurgical hospital, highlighting the predominance of ICU-associated cases, late-onset infections, and antimicrobial-resistant phenotypes. These findings support the need for continued epidemiological surveillance and antimicrobial resistance monitoring in high-risk neurosurgical settings.

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Cite

BibTeXRIS
BibTeX
@article{luchian2026healthcareassociated,
  title = {{Healthcare-Associated Infections with Pseudomonas spp. in a Neurosurgical Hospital: Epidemiological and Clinical Insights.}},
  author = {Nicoleta Luchian and Cristian Guțu and Camer Salim and Alina Pleșea-Condratovici and Marius Gabriel Dabija and Mădălina Irina Ciuhodaru and Mădălina Duceac Covrig and Constantin Marcu and Irina Luciana Gurzu and Petruța Iuliana Moraru and Mădălina Nicoleta Matei and Letiția Doina Duceac},
  journal = {Medicina (Kaunas, Lithuania)},
  year = {2026},
  month = oct,
  doi = {10.3390/medicina62102019},
  url = {https://europepmc.org/article/MED/42942550},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Healthcare-Associated Infections with Pseudomonas spp. in a Neurosurgical Hospital: Epidemiological and Clinical Insights.
AU  - Nicoleta Luchian
AU  - Cristian Guțu
AU  - Camer Salim
AU  - Alina Pleșea-Condratovici
AU  - Marius Gabriel Dabija
AU  - Mădălina Irina Ciuhodaru
AU  - Mădălina Duceac Covrig
AU  - Constantin Marcu
AU  - Irina Luciana Gurzu
AU  - Petruța Iuliana Moraru
AU  - Mădălina Nicoleta Matei
AU  - Letiția Doina Duceac
PY  - 2026
DA  - 2026/10/19
JO  - Medicina (Kaunas, Lithuania)
DO  - 10.3390/medicina62102019
UR  - https://europepmc.org/article/MED/42942550
AB  - Background and Objectives: Healthcare-associated infections (HAIs) caused by Pseudomonas aeruginosa represent a challenge for healthcare systems worldwide, with significant incidence, high mortality, and increasing antibiotic resistance. This paper aims to describe and analyze the epidemiology of HAI cases with Pseudomonas aeruginosa in a tertiary neurosurgical hospital in the northeastern region of Romania during 2020-2024. Materials and Methods: Study inclusion criteria were patients of any age (as the hospital also admits pediatric patients from the region) and a diagnosis of P. aeruginosa HAI, with a signed informed consent form by the adult patient or relatives for pediatric patients. Results: During 2020-2024, 163 cases of P. aeruginosa HAIs were identified. The annual incidence decreased from 4.41‱ in 2020 to 2.37‱ in 2024 (p = 0.0038). Most cases occurred in the intensive care unit (ICU) (119/163; 73.0%), followed by neurosurgery wards (37/163; 22.7%). Overall, 110 cases (67.5%) occurred in men and 53 (32.5%) in women. The analysis also showed a predominance of late-onset cases and the presence of antimicrobial-resistant phenotypes among the identified P. aeruginosa isolates. Conclusions: This study provides an integrated epidemiological characterization of P. aeruginosa HAIs in a regional neurosurgical hospital, highlighting the predominance of ICU-associated cases, late-onset infections, and antimicrobial-resistant phenotypes. These findings support the need for continued epidemiological surveillance and antimicrobial resistance monitoring in high-risk neurosurgical settings.
SN  - 1010-660X
SN  - 1648-9144
ER  -