What influences food choices in anorexia nervosa? Disentangling cognitive and emotional components of decision-making by translational research
Abstract
Anorexia nervosa is a serious mental illness characterized by voluntary restriction of food intake and avoidance of high-calorie food. Anxiety, highly comorbid with anorexia nervosa, appears to be a significant, yet underexplored, factor affecting core behavioural symptoms such as food restriction and compulsive physical exercise. The aims of this review are to disentangle the influence of anxiety in food decision-making in anorexia nervosa and to offer a comprehensive model connecting the mechanisms involved. The shift from food approach to avoidance seems to be a conditioned response, underpinned by an activation of salience and fear circuitry. Altered neurotransmission (dopamine, serotonin) and neuroendocrine release (leptin, ghrelin, cortisol), aberrant neural structure activation (hyperactivation of the amygdala and hypoactivation of the insula-ventral striatum circuit) and cognitive and behavioural traits shared by anxiety and anorexia nervosa (rigidity, compulsiveness) contribute to these modifications. Animal models suggest a bidirectional relationship between food restriction and anorectic-like behaviours, strengthening yet complexifying the link between anxiety and food choice in anorexia nervosa. Therapeutic strategies focusing on anxiety and the conditioned response could contribute to restore healthy food choices and dissociate food stimuli from the anxious response elicited.
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BibTeX
@article{lodovico2026what,
title = {{What influences food choices in anorexia nervosa? Disentangling cognitive and emotional components of decision-making by translational research}},
author = {Laura Di Lodovico and Héloise Hamelin and Lucas Dezorzi and Chloe Tezenas Du Montcel and Erik Schéle and Iris Stoltenborg and Roger Adan and Suzanne Dickson and Philip Gorwood and Virginie Tolle and Odile Viltart},
journal = {Neuroscience Applied},
year = {2026},
month = sep,
doi = {10.1016/j.nsa.2024.104080},
url = {https://hal.science/hal-05751765v1},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - What influences food choices in anorexia nervosa? Disentangling cognitive and emotional components of decision-making by translational research
AU - Laura Di Lodovico
AU - Héloise Hamelin
AU - Lucas Dezorzi
AU - Chloe Tezenas Du Montcel
AU - Erik Schéle
AU - Iris Stoltenborg
AU - Roger Adan
AU - Suzanne Dickson
AU - Philip Gorwood
AU - Virginie Tolle
AU - Odile Viltart
PY - 2026
DA - 2026/09/16
JO - Neuroscience Applied
DO - 10.1016/j.nsa.2024.104080
UR - https://hal.science/hal-05751765v1
AB - Anorexia nervosa is a serious mental illness characterized by voluntary restriction of food intake and avoidance of high-calorie food. Anxiety, highly comorbid with anorexia nervosa, appears to be a significant, yet underexplored, factor affecting core behavioural symptoms such as food restriction and compulsive physical exercise. The aims of this review are to disentangle the influence of anxiety in food decision-making in anorexia nervosa and to offer a comprehensive model connecting the mechanisms involved. The shift from food approach to avoidance seems to be a conditioned response, underpinned by an activation of salience and fear circuitry. Altered neurotransmission (dopamine, serotonin) and neuroendocrine release (leptin, ghrelin, cortisol), aberrant neural structure activation (hyperactivation of the amygdala and hypoactivation of the insula-ventral striatum circuit) and cognitive and behavioural traits shared by anxiety and anorexia nervosa (rigidity, compulsiveness) contribute to these modifications. Animal models suggest a bidirectional relationship between food restriction and anorectic-like behaviours, strengthening yet complexifying the link between anxiety and food choice in anorexia nervosa. Therapeutic strategies focusing on anxiety and the conditioned response could contribute to restore healthy food choices and dissociate food stimuli from the anxious response elicited.
SN - 2772-4085
ER -