Carbon dots in tissue repair: from cell behavior to microenvironment remodeling.
- 1School of Stomatology, Stomatological Hospital, Southern Medical University, Guangzhou, China.
- 2Hunan Key Laboratory of Oral Health Research, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Xiangya Stomatological Hospital, Xiangya School of Stomatology Central South University, Changsha, China.
- 3Department of Stomatology, Changsha Stomatological Hospital, Changsha, China.
Abstract
Tissue repair is essential for restoring structural integrity and function after injury. Carbon dots (CDs) have garnered considerable interest in biomedicine due to their high specific surface area, excellent water solubility, biocompatibility, and facile doping and surface functionalization. Within biological systems, CDs facilitate tissue repair through multifaceted mechanisms: they restore cellular functions by enhancing migration, proliferation, and differentiation while suppressing senescence and apoptosis; simultaneously, they modulate the injured microenvironment via antioxidant and immunoregulatory effects. Despite growing research, a comprehensive review detailing the roles of CDs in tissue repair remains unavailable. This review addresses this gap by systematically summarizing CDs' applications across various tissue types and elucidating their underlying mechanisms. Additionally, it critiques current research limitations and provides future perspectives, offering both theoretical insights and practical guidance for advancing CDs-based repair materials.
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BibTeX
@article{li2026carbon,
title = {{Carbon dots in tissue repair: from cell behavior to microenvironment remodeling.}},
author = {Xumin Li and Junsi Luo and Shuangjiang Li},
journal = {Frontiers in bioengineering and biotechnology},
year = {2026},
month = oct,
doi = {10.3389/fbioe.2026.1912437},
url = {https://europepmc.org/article/MED/42898650},
note = {CC BY},
}
RIS
TY - JOUR
TI - Carbon dots in tissue repair: from cell behavior to microenvironment remodeling.
AU - Xumin Li
AU - Junsi Luo
AU - Shuangjiang Li
PY - 2026
DA - 2026/10/05
JO - Frontiers in bioengineering and biotechnology
DO - 10.3389/fbioe.2026.1912437
UR - https://europepmc.org/article/MED/42898650
AB - Tissue repair is essential for restoring structural integrity and function after injury. Carbon dots (CDs) have garnered considerable interest in biomedicine due to their high specific surface area, excellent water solubility, biocompatibility, and facile doping and surface functionalization. Within biological systems, CDs facilitate tissue repair through multifaceted mechanisms: they restore cellular functions by enhancing migration, proliferation, and differentiation while suppressing senescence and apoptosis; simultaneously, they modulate the injured microenvironment via antioxidant and immunoregulatory effects. Despite growing research, a comprehensive review detailing the roles of CDs in tissue repair remains unavailable. This review addresses this gap by systematically summarizing CDs' applications across various tissue types and elucidating their underlying mechanisms. Additionally, it critiques current research limitations and provides future perspectives, offering both theoretical insights and practical guidance for advancing CDs-based repair materials.
SN - 2296-4185
ER -