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Peer-reviewedCC BY 4.0npj Women's Health

Parabens and estrogen-mediated cancers: unraveling coincidence, co-occurrence, and causality

  • Zehra Esra Ilhan
  • Andrea Marchetto
  • Georgia Lorentzen
  • Paweł Łaniewski
  • Leslie V Farland
  • Melissa M Herbst-Kralovetz
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Abstract

Paraben esters are endocrine disruptors linked to breast cancer, yet their role in other estrogen-mediated cancers remains limited. Preclinical evidence suggests that parabens accumulate in tissues and may promote carcinogenesis, while clinical data indicate widespread exposure. Our re-analysis of cervicovaginal metabolomes revealed elevated paraben metabolites in endometrial and cervical cancer patients compared with controls. Overall, longitudinal studies considering intrinsic and environmental factors are needed in assessing paraben-related cancer risk.

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Cite

BibTeXRIS
BibTeX
@article{ilhan2026parabens,
  title = {{Parabens and estrogen-mediated cancers: unraveling coincidence, co-occurrence, and causality}},
  author = {Zehra Esra Ilhan and Andrea Marchetto and Georgia Lorentzen and Paweł Łaniewski and Leslie V Farland and Melissa M Herbst-Kralovetz},
  journal = {npj Women's Health},
  year = {2026},
  month = aug,
  doi = {10.1038/s44294-026-00162-7},
  url = {https://hal.science/hal-05766346v1},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Parabens and estrogen-mediated cancers: unraveling coincidence, co-occurrence, and causality
AU  - Zehra Esra Ilhan
AU  - Andrea Marchetto
AU  - Georgia Lorentzen
AU  - Paweł Łaniewski
AU  - Leslie V Farland
AU  - Melissa M Herbst-Kralovetz
PY  - 2026
DA  - 2026/08/28
JO  - npj Women's Health
DO  - 10.1038/s44294-026-00162-7
UR  - https://hal.science/hal-05766346v1
AB  - Paraben esters are endocrine disruptors linked to breast cancer, yet their role in other estrogen-mediated cancers remains limited. Preclinical evidence suggests that parabens accumulate in tissues and may promote carcinogenesis, while clinical data indicate widespread exposure. Our re-analysis of cervicovaginal metabolomes revealed elevated paraben metabolites in endometrial and cervical cancer patients compared with controls. Overall, longitudinal studies considering intrinsic and environmental factors are needed in assessing paraben-related cancer risk.
SN  - 2948-1716
SN  - 2948-1716
ER  -