Investigating the Relationship Between Mitral Leaflet Separation Index and Severity of Mitral Valve Stenosis Using Two and Three-Dimensional Measurement Methods in Trans Esophageal Echocardiography.
- 1Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
- 2Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Abstract
Introduction
Cardiologists use several echocardiographic methods to evaluate the Mitral Stenosis (MS) severity. Determination of mitral valve area (MVA) by three- dimensional transesophageal echocardiography (3D TEE) planimetry has the best correlation with anatomic area of the mitral orifice and is probably the reference method. This study was designed to examine the relationship between mitral leaflet separation index (MLSI) measured by TEE which is a simple and accessible method and MVA calculated by 3D Multiplanar reconstruction (3D-MPR) planimetry in TEE as the reference but less accessible method for evaluation the MLSI accuracy in prediction of the severity of MS.Methods
72 patients with MS were included in this study. Exclusion criteria were suboptimal echocardiographic images, severe mitral valve calcification, artificial heart valves, a history of mitral valve repair surgery, or contraindications to TEE. After obtaining written informed consents from all patients. Comprehensive TTE and TEE were performed and MLSI by 2D TTE and 2D TEE and MVA by 3D MPR planimetry were assessed. SPSS version 25 was used for performing the analysis and a P-value less than 0.05 was considered statistically significant.Results
The average age of the patients was 57.81±12.22 and of the patients were female. There was a significant correlation between MVA by 3D MPR and MLSI 2D TTE (r=0.94, P<0.01) and MLSI 2D TEE (r=0.96, P<0.01) methods.Conclusion
MLSI 2D TTE and MLSI 2D TEE are positively correlated to MVA measured by 3D MPR planimetry and MLSI can be useful in discriminating different grades of MS severity.
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BibTeX
@article{hoshmand2026investigating,
title = {{Investigating the Relationship Between Mitral Leaflet Separation Index and Severity of Mitral Valve Stenosis Using Two and Three-Dimensional Measurement Methods in Trans Esophageal Echocardiography.}},
author = {Alaaldin Hoshmand and Naser Khezerlouy-Aghdam and Rezvanieh Salehi and Somayeh Abolhasani and Elnaz Javanshir},
journal = {Journal of cardiovascular and thoracic research},
year = {2026},
month = jun,
doi = {10.34172/jcvtr.33359},
url = {https://europepmc.org/article/MED/42898370},
note = {CC BY},
}
RIS
TY - JOUR
TI - Investigating the Relationship Between Mitral Leaflet Separation Index and Severity of Mitral Valve Stenosis Using Two and Three-Dimensional Measurement Methods in Trans Esophageal Echocardiography.
AU - Alaaldin Hoshmand
AU - Naser Khezerlouy-Aghdam
AU - Rezvanieh Salehi
AU - Somayeh Abolhasani
AU - Elnaz Javanshir
PY - 2026
DA - 2026/06/30
JO - Journal of cardiovascular and thoracic research
DO - 10.34172/jcvtr.33359
UR - https://europepmc.org/article/MED/42898370
AB - Introduction Cardiologists use several echocardiographic methods to evaluate the Mitral Stenosis (MS) severity. Determination of mitral valve area (MVA) by three- dimensional transesophageal echocardiography (3D TEE) planimetry has the best correlation with anatomic area of the mitral orifice and is probably the reference method. This study was designed to examine the relationship between mitral leaflet separation index (MLSI) measured by TEE which is a simple and accessible method and MVA calculated by 3D Multiplanar reconstruction (3D-MPR) planimetry in TEE as the reference but less accessible method for evaluation the MLSI accuracy in prediction of the severity of MS.Methods 72 patients with MS were included in this study. Exclusion criteria were suboptimal echocardiographic images, severe mitral valve calcification, artificial heart valves, a history of mitral valve repair surgery, or contraindications to TEE. After obtaining written informed consents from all patients. Comprehensive TTE and TEE were performed and MLSI by 2D TTE and 2D TEE and MVA by 3D MPR planimetry were assessed. SPSS version 25 was used for performing the analysis and a P-value less than 0.05 was considered statistically significant.Results The average age of the patients was 57.81±12.22 and of the patients were female. There was a significant correlation between MVA by 3D MPR and MLSI 2D TTE (r=0.94, P<0.01) and MLSI 2D TEE (r=0.96, P<0.01) methods.Conclusion MLSI 2D TTE and MLSI 2D TEE are positively correlated to MVA measured by 3D MPR planimetry and MLSI can be useful in discriminating different grades of MS severity.
SN - 2008-5117
SN - 2008-6830
ER -