PreprintCC BYbioRxiv
Studies on a luminescent antimicrobial metal complex reveal a method to directly image pathogenic bacterial infection in a living organism using optical microscopy
- 1University of Sheffield
Abstract
Methods to render Galleria Mellonella larvae transparent allowing three-dimensional viewing of larvae through orthodox light microscopy techniques are reported. To explore this models capability, we exploited the imaging properties of a metal complex antimicrobial to probe its therapeutic action against a pathogenic Acetinobacter baumannii infection. To illustrate the general utility of this method, we have also used the commercial fluorescent dye, Alexafluor-488, to image bacteria within live larvae.
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BibTeX
@misc{thomas2026studies,
title = {{Studies on a luminescent antimicrobial metal complex reveal a method to directly image pathogenic bacterial infection in a living organism using optical microscopy}},
author = {J. A. Thomas},
howpublished = {bioRxiv},
year = {2026},
month = oct,
doi = {10.64898/2026.10.21.760849},
url = {https://www.biorxiv.org/content/10.64898/2026.10.21.760849v1},
note = {CC BY},
}
RIS
TY - UNPB
TI - Studies on a luminescent antimicrobial metal complex reveal a method to directly image pathogenic bacterial infection in a living organism using optical microscopy
AU - J. A. Thomas
PY - 2026
DA - 2026/10/21
PB - bioRxiv
DO - 10.64898/2026.10.21.760849
UR - https://www.biorxiv.org/content/10.64898/2026.10.21.760849v1
AB - Methods to render Galleria Mellonella larvae transparent allowing three-dimensional viewing of larvae through orthodox light microscopy techniques are reported. To explore this models capability, we exploited the imaging properties of a metal complex antimicrobial to probe its therapeutic action against a pathogenic Acetinobacter baumannii infection. To illustrate the general utility of this method, we have also used the commercial fluorescent dye, Alexafluor-488, to image bacteria within live larvae.
ER -