Skip to content
DraconiticResearch
Search Sources API
201,818 studies31 sourcesUpdated 55 min ago
Peer-reviewedCC BY-NC-NDAnnals of Hepatology

Association between grip strength and cause-specific mortality in metabolic dysfunction-associated steatotic liver disease

  • Chao Li1
  • Zhijia Zhao2
  • Ying Che1
  • Yu Su1
  • Wei Li3
  1. 1Department of Gastroenterology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
  2. 2Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, China
  3. 3Department of Gastroenterology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China; Corresponding author.
Read full textDOICite

Abstract

Introduction and Objectives: Impaired muscle strength is increasingly recognized as an integrative marker of metabolic dysfunction and adverse prognosis. This study aimed to examine the associations between grip strength and cause-specific mortality in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). Patients and Methods: This cohort study included 92,263 individuals with MASLD from the UK Biobank. Grip strength was categorized into sex-specific tertiles. We used Cox proportional hazards models and restricted cubic splines to assess associations between grip strength and the risks of mortality, including all-cause mortality and cause-specific mortality (cardiovascular, extrahepatic cancer, liver, and diabetes-related mortality). Results: During a median follow-up of 13.3 years, 9923 deaths were documented. Restricted cubic splines indicated that grip strength showed linear associations with both all-cause mortality and cause-specific mortality. Compared to high grip strength, low grip strength was associated with increased risks of all-cause mortality (HR=1.36, 95% CI 1.28–1.43), cardiovascular-related mortality (HR=1.54, 95% CI 1.28–1.87), cancer-related mortality (HR=1.25, 95% CI 1.14–1.38), liver-related mortality (HR=1.76, 95% CI 1.08–2.87) and diabetes-related mortality (HR=2.40, 95% CI 1.36–4.23). These associations were generally consistent across age and sex subgroups. Notably, the protective association between high grip strength and reduced risk of cardiovascular mortality was more pronounced in participants aged ≥60 years (HR=0.86, 95% CI 0.82–0.91) compared to those <60 years (HR=0.96, 95% CI 0.88–1.04). Conclusions: Lower grip strength was associated with increased risks of all-cause mortality and cause-specific mortality in patients with MASLD. Muscle strength management may be considered as part of the care strategy for MASLD patients.

Related

  1. METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE: ASSOCIATION WITH BODY MASS INDEX AND DISEASE SEVERITY
    A. Antoniv, N. Antoniv
    medRxivPreprintCC BY-NC-NDFull textEpidemiology & public healthmedRxiv
  2. Thyroid-stimulating hormone–body mass index profile and mortality in metabolic dysfunction-associated steatotic liver disease
    Jie Xu, Jun-Zhe Yi, Ping Chen +16
    ILIVERPeer-reviewedCC BY-NC-ND 4.0Full textGeneral medicinePMC
  3. Association of the nutritional metabolic risk index with metabolic dysfunction-associated steatotic liver disease in a sub-plateau population
    Huanqiong Fan, Minjie He, Guosong Jiang +3
    Frontiers in endocrinologyPeer-reviewedCC BYFull textEpidemiology & public healthEurope PMCCrossref
  4. Association of longitudinal serum 25-hydroxyvitamin D trajectories with subsequent liver stiffness increase in patients with early-onset type 2 diabetes and metabolic dysfunction-associated steatotic liver disease
    Hong Ji, Runzhou Pan, Xiaowei Huang
    Frontiers in EndocrinologyPeer-reviewedCC BY 4.0Full textEpidemiology & public healthCrossref
  5. Association between vitamin D deficiency and liver fibrosis assessed by transient elastography in patients with metabolic dysfunction-associated steatotic liver disease.
    Justin Jose, Salman Muhammad Soomar, Ximena Fernandez Cristobal +1
    BMC endocrine disordersPeer-reviewedCC BYFull textEpidemiology & public healthEurope PMCPMC

Cite

BibTeXRIS
BibTeX
@article{li2026association,
  title = {{Association between grip strength and cause-specific mortality in metabolic dysfunction-associated steatotic liver disease}},
  author = {Chao Li and Zhijia Zhao and Ying Che and Yu Su and Wei Li},
  journal = {Annals of Hepatology},
  year = {2026},
  month = oct,
  doi = {10.1016/j.aohep.2026.102252},
  url = {https://doi.org/10.1016/j.aohep.2026.102252},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Association between grip strength and cause-specific mortality in metabolic dysfunction-associated steatotic liver disease
AU  - Chao Li
AU  - Zhijia Zhao
AU  - Ying Che
AU  - Yu Su
AU  - Wei Li
PY  - 2026
DA  - 2026/10/31
JO  - Annals of Hepatology
DO  - 10.1016/j.aohep.2026.102252
UR  - https://doi.org/10.1016/j.aohep.2026.102252
AB  - Introduction and Objectives: Impaired muscle strength is increasingly recognized as an integrative marker of metabolic dysfunction and adverse prognosis. This study aimed to examine the associations between grip strength and cause-specific mortality in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). Patients and Methods: This cohort study included 92,263 individuals with MASLD from the UK Biobank. Grip strength was categorized into sex-specific tertiles. We used Cox proportional hazards models and restricted cubic splines to assess associations between grip strength and the risks of mortality, including all-cause mortality and cause-specific mortality (cardiovascular, extrahepatic cancer, liver, and diabetes-related mortality). Results: During a median follow-up of 13.3 years, 9923 deaths were documented. Restricted cubic splines indicated that grip strength showed linear associations with both all-cause mortality and cause-specific mortality. Compared to high grip strength, low grip strength was associated with increased risks of all-cause mortality (HR=1.36, 95% CI 1.28–1.43), cardiovascular-related mortality (HR=1.54, 95% CI 1.28–1.87), cancer-related mortality (HR=1.25, 95% CI 1.14–1.38), liver-related mortality (HR=1.76, 95% CI 1.08–2.87) and diabetes-related mortality (HR=2.40, 95% CI 1.36–4.23). These associations were generally consistent across age and sex subgroups. Notably, the protective association between high grip strength and reduced risk of cardiovascular mortality was more pronounced in participants aged ≥60 years (HR=0.86, 95% CI 0.82–0.91) compared to those <60 years (HR=0.96, 95% CI 0.88–1.04). Conclusions: Lower grip strength was associated with increased risks of all-cause mortality and cause-specific mortality in patients with MASLD. Muscle strength management may be considered as part of the care strategy for MASLD patients.
SN  - 1665-2681
SN  - 2659-5982
ER  -