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Peer-reviewedCC BY-NC-ND 4.0Veterinary Medicine and Science

Chondroprotective Effect of PCSO‐524 (Green‐Lipped Mussel Extraction) Application Evaluated by Ultrasonography in Pomeranian and Chihuahua With Medial Patellar Luxation Grade II

  • Kumpanart Soontornvipart1
  • Ratthanan Sathienbumrungkit1,2
  1. 1Department of Veterinary Surgery Faculty of Veterinary Science Chulalongkorn University Bangkok Thailand
  2. 2Faculty of Veterinary Science Small Animal Hospital Chulalongkorn University Bangkok Thailand
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Abstract

Objective: This research evaluated the chondroprotective efficacy of PCSO‐524 in dogs with osteoarthritis (OA) secondary to medial patellar luxation (MPL) using ultrasonography − a non‐invasive technique recommended for early OA detection.

Materials and Methods: Animals: 25 dogs total (21 with MPL grade II, 50 stifle joints evaluated) divided into three groups, including control group: 10 dogs receiving placebo, treatment group: 11 dogs receiving PCSO‐524 (50 mg daily) and normal group: 4 healthy dogs (reference)

Duration: 16 weeks

Evaluations: Lameness scores, blood profiles, ultrasonographic findings, radiographic assessments and owner questionnaires at baseline, weeks 2, 4, 8, 12 and 16.

Results: The treatment group showed significant improvement in lameness scores within 8 weeks. The cartilage lesions improved within 4 weeks of PCSO‐524 administration. Synovial fluid scores decreased significantly by week 4 in the treatment group. Radiographic OA scores improved mildly at 12 weeks in the treatment group versus progression in the control group. Owners observed better gait and quality of life by week 2. No adverse effects on blood chemistry or organ function.

Conclusion: PCSO‐524 demonstrates effective cartilage protection in dogs with OA secondary to MPL, with improvements in clinical signs, ultrasonographic findings and radiographic outcomes. For dogs that cannot undergo surgical correction, PCSO‐524 supplementation combined with quadriceps muscle training and environmental management is recommended for improved quality of life.

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Cite

BibTeXRIS
BibTeX
@article{soontornvipart2026chondroprotective,
  title = {{Chondroprotective Effect of PCSO‐524 (Green‐Lipped Mussel Extraction) Application Evaluated by Ultrasonography in Pomeranian and Chihuahua With Medial Patellar Luxation Grade II}},
  author = {Kumpanart Soontornvipart and Ratthanan Sathienbumrungkit},
  journal = {Veterinary Medicine and Science},
  year = {2026},
  month = oct,
  doi = {10.1002/vms3.71304},
  url = {https://doi.org/10.1002/vms3.71304},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Chondroprotective Effect of PCSO‐524 (Green‐Lipped Mussel Extraction) Application Evaluated by Ultrasonography in Pomeranian and Chihuahua With Medial Patellar Luxation Grade II
AU  - Kumpanart Soontornvipart
AU  - Ratthanan Sathienbumrungkit
PY  - 2026
DA  - 2026/10/27
JO  - Veterinary Medicine and Science
DO  - 10.1002/vms3.71304
UR  - https://doi.org/10.1002/vms3.71304
AB  - Objective: This research evaluated the chondroprotective efficacy of PCSO‐524 in dogs with osteoarthritis (OA) secondary to medial patellar luxation (MPL) using ultrasonography − a non‐invasive technique recommended for early OA detection.  Materials and Methods: Animals: 25 dogs total (21 with MPL grade II, 50 stifle joints evaluated) divided into three groups, including control group: 10 dogs receiving placebo, treatment group: 11 dogs receiving PCSO‐524 (50 mg daily) and normal group: 4 healthy dogs (reference)  Duration: 16 weeks  Evaluations: Lameness scores, blood profiles, ultrasonographic findings, radiographic assessments and owner questionnaires at baseline, weeks 2, 4, 8, 12 and 16.  Results: The treatment group showed significant improvement in lameness scores within 8 weeks. The cartilage lesions improved within 4 weeks of PCSO‐524 administration. Synovial fluid scores decreased significantly by week 4 in the treatment group. Radiographic OA scores improved mildly at 12 weeks in the treatment group versus progression in the control group. Owners observed better gait and quality of life by week 2. No adverse effects on blood chemistry or organ function.  Conclusion: PCSO‐524 demonstrates effective cartilage protection in dogs with OA secondary to MPL, with improvements in clinical signs, ultrasonographic findings and radiographic outcomes. For dogs that cannot undergo surgical correction, PCSO‐524 supplementation combined with quadriceps muscle training and environmental management is recommended for improved quality of life.
SN  - 2053-1095
ER  -