3-O-p-coumaroylquinic acid and 4-O-p-coumaroylquinic acid from Hemerocallis citrina Baroni exert antidepressant effects via CA/Dopa/DA/NE and PKA/CREB/BDNF signaling pathways
- 1College of Veterinary Medicine, Hunan Agricultural University
- 2College of tea culture, Hunan Vocational College of Commerce
Abstract
The ancient text “Compendium of Materia Medica” records that Hemerocallis citrina Baroni (daylily) was used for antidepressant, but its active components and mechanisms remain unknown. In this study, the H. citrina extract was initially fractionated into three parts, and only the 35% HCW (35% ethanol-eluted fraction of Hemerocallis citrina water extract, LILYANTIDEPRES®) demonstrated significant antidepressant activity, notably increasing the levels of dopamine (DA), norepinephrine (NE), and brain-derived neurotrophic factor (BDNF) in the brain of depressed mice. It’s also significantly reducing the IL-6 (Interleukin-6) and MDA (Malondialdehyde) levels, and improving the gut microbiota. The main components of the 35% HCW were identified as 3-O-p-coumaroylquinic acid (1) and 4-O-p-coumaroylquinic acid (2), which were also chemically synthesized. Both compounds exhibited significant antidepressant activity by increasing the levels of DA, NE, and BDNF in the brain of depressed mice and significantly reducing the levels of IL-6 and TNF-α (Tumor Necrosis Factor-α). A potential mechanism to elevate DA and NE levels in the depressed mice brain via the CA (coumaroylquinic acid)/Dopa/DA/NE pathway. Additionally, compounds 1 and 2 significantly increase BDNF levels through the PKA (Protein Kinase A)/CREB (cAMP Response Element-Binding Protein)/BDNF signaling pathway. This study provides the first elucidation of the antidepressant components of H. citrina and the mechanisms, laying the foundation for the development of antidepressant products and the high-value utilization of H. citrina resources.
Related
- Excitatory neuronal TIA1 in ventral hippocampal CA1 drives antidepressant-like effects via downregulation of Cacna2d1 signaling in mice
- Convergent neuroimmune signaling underlying rapid antidepressant response to ketamine and psychedelics
- Enhanced Antileukemic Efficacy of Venetoclax-Loaded PEG-PLGA Nanoparticles Against THP-1 Acute Monocytic Leukemia Cells via Suppression of BCL-2 and Pro-Survival Signaling Pathways
- Bioactive compounds from Perilla frutescens modulate multiple cell death pathways and signaling networks in cancer therapy
- VGLL4 Suppresses Malignant Phenotypes of Clear Cell Renal Cell Carcinoma Cells Through Modulation of Hippo/YAP and Wnt/β-Catenin Signaling Pathways
BibTeX
@article{jiang20263opcoumaroylquinic,
title = {{3-O-p-coumaroylquinic acid and 4-O-p-coumaroylquinic acid from Hemerocallis citrina Baroni exert antidepressant effects via CA/Dopa/DA/NE and PKA/CREB/BDNF signaling pathways}},
author = {Faying Jiang and Zhengyue Qiu and Juhua Zhong and Tian Ye and Jinghong Liu and Yishuo Zhu and Lewei Zhao and Siyu Chen and Hongbao Chen and Haobo Wang and Lin Kang and Tonghe Yang and Shuai Li and Si Liu and Jianguo Zeng and Zhixing Qing},
journal = {npj Science of Food},
year = {2026},
month = jul,
doi = {10.1038/s41538-026-00934-0},
url = {https://doi.org/10.1038/s41538-026-00934-0},
note = {CC BY},
}
RIS
TY - JOUR
TI - 3-O-p-coumaroylquinic acid and 4-O-p-coumaroylquinic acid from Hemerocallis citrina Baroni exert antidepressant effects via CA/Dopa/DA/NE and PKA/CREB/BDNF signaling pathways
AU - Faying Jiang
AU - Zhengyue Qiu
AU - Juhua Zhong
AU - Tian Ye
AU - Jinghong Liu
AU - Yishuo Zhu
AU - Lewei Zhao
AU - Siyu Chen
AU - Hongbao Chen
AU - Haobo Wang
AU - Lin Kang
AU - Tonghe Yang
AU - Shuai Li
AU - Si Liu
AU - Jianguo Zeng
AU - Zhixing Qing
PY - 2026
DA - 2026/07/01
JO - npj Science of Food
DO - 10.1038/s41538-026-00934-0
UR - https://doi.org/10.1038/s41538-026-00934-0
AB - The ancient text “Compendium of Materia Medica” records that Hemerocallis citrina Baroni (daylily) was used for antidepressant, but its active components and mechanisms remain unknown. In this study, the H. citrina extract was initially fractionated into three parts, and only the 35% HCW (35% ethanol-eluted fraction of Hemerocallis citrina water extract, LILYANTIDEPRES®) demonstrated significant antidepressant activity, notably increasing the levels of dopamine (DA), norepinephrine (NE), and brain-derived neurotrophic factor (BDNF) in the brain of depressed mice. It’s also significantly reducing the IL-6 (Interleukin-6) and MDA (Malondialdehyde) levels, and improving the gut microbiota. The main components of the 35% HCW were identified as 3-O-p-coumaroylquinic acid (1) and 4-O-p-coumaroylquinic acid (2), which were also chemically synthesized. Both compounds exhibited significant antidepressant activity by increasing the levels of DA, NE, and BDNF in the brain of depressed mice and significantly reducing the levels of IL-6 and TNF-α (Tumor Necrosis Factor-α). A potential mechanism to elevate DA and NE levels in the depressed mice brain via the CA (coumaroylquinic acid)/Dopa/DA/NE pathway. Additionally, compounds 1 and 2 significantly increase BDNF levels through the PKA (Protein Kinase A)/CREB (cAMP Response Element-Binding Protein)/BDNF signaling pathway. This study provides the first elucidation of the antidepressant components of H. citrina and the mechanisms, laying the foundation for the development of antidepressant products and the high-value utilization of H. citrina resources.
SN - 2396-8370
ER -