Lung Cancer Initially Presenting with Diffuse Alveolar Damage and Brain Infarction: An Autopsy Case Report

Abstract

A 67-year-old man presented with dyspnea, right hemiparesis, and dysarthria. Chest computed tomography revealed extensive pulmonary infiltrates and a small nodule in the left upper lobe. Brain magnetic resonance imaging revealed multiple acute cerebral infarctions. Despite comprehensive management, the patient died from progressive respiratory failure. Autopsy revealed pleomorphic carcinoma of the lung (pT1bN1M1c, pStage IVB), diffuse alveolar damage (DAD), and nonbacterial thrombotic endocarditis. To the best of our knowledge, this is the first report of lung cancer initially diagnosed based on the simultaneous presentation of DAD and cerebral infarction. The rarity and concurrence of these manifestations suggest a potential paraneoplastic link.

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Cite

BibTeX RIS

BibTeX

@article{ikeda2026lung,
  title = {{Lung Cancer Initially Presenting with Diffuse Alveolar Damage and Brain Infarction: An Autopsy Case Report}},
  author = {Taiki Ikeda and Yoshiaki Kinoshita and Masayo Yoshimura and Michiko Nakashima and Kengo Takata and Keita Hara and Chiharu Hirai and Takuhide Utsunomiya and Shota Nakashima and Hisako Kushima and Satoshi Nimura and Hiroshi Ishii},
  journal = {Internal Medicine},
  year = {2026},
  month = oct,
  doi = {10.2169/internalmedicine.6806-25},
  url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/20/65_6806-25/_article},
  note = {CC BY-NC-ND},
}

RIS

TY  - JOUR
TI  - Lung Cancer Initially Presenting with Diffuse Alveolar Damage and Brain Infarction: An Autopsy Case Report
AU  - Taiki Ikeda
AU  - Yoshiaki Kinoshita
AU  - Masayo Yoshimura
AU  - Michiko Nakashima
AU  - Kengo Takata
AU  - Keita Hara
AU  - Chiharu Hirai
AU  - Takuhide Utsunomiya
AU  - Shota Nakashima
AU  - Hisako Kushima
AU  - Satoshi Nimura
AU  - Hiroshi Ishii
PY  - 2026
DA  - 2026/10/15
JO  - Internal Medicine
DO  - 10.2169/internalmedicine.6806-25
UR  - https://www.jstage.jst.go.jp/article/internalmedicine/65/20/65_6806-25/_article
AB  - A 67-year-old man presented with dyspnea, right hemiparesis, and dysarthria. Chest computed tomography revealed extensive pulmonary infiltrates and a small nodule in the left upper lobe. Brain magnetic resonance imaging revealed multiple acute cerebral infarctions. Despite comprehensive management, the patient died from progressive respiratory failure. Autopsy revealed pleomorphic carcinoma of the lung (pT1bN1M1c, pStage IVB), diffuse alveolar damage (DAD), and nonbacterial thrombotic endocarditis. To the best of our knowledge, this is the first report of lung cancer initially diagnosed based on the simultaneous presentation of DAD and cerebral infarction. The rarity and concurrence of these manifestations suggest a potential paraneoplastic link.
SN  - 1349-7235
SN  - 0918-2918
ER  -

Abstract

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