Histopathologic Characterization of Cutaneous Oxalosis Mimicking Calciphylaxis: Diagnostic Pitfalls and Polarized Light Evaluation
- 1Department of Dermatology University of Texas at Tyler School of Medicine Tyler Texas USA
- 2U.S. Dermatology Partners Tyler Texas USA
Abstract
Cutaneous oxalosis is an uncommon manifestation of primary hyperoxalosis, which can often resemble other cutaneous manifestations of end stage renal disease (ESRD), particularly calciphylaxis. We report the case of a 46 year old female with primary hyperoxaluria type one (PH1) believed to be well‐controlled on lumasiran, a small interfering ribonucleic acid therapy, which targets the mRNA responsible for producing hydroxyacid oxidase 1 (HAO1) and through reduction of this enzyme, decreases the hepatic overproduction of oxalate. The patient presented for dermatologic evaluation of presumed calciphylaxis. Repeated skin biopsies, however, confirmed cutaneous oxalosis despite perceived stable metabolic control with lumasiran. This case highlights the complexities and challenges in the diagnosis of cutaneous manifestations of chronic kidney disease and emphasizes the importance of histopathologic evaluation, even if the patient's primary hyperoxaluria is believed to be well‐controlled.
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BibTeX
@article{patel2026histopathologic,
title = {{Histopathologic Characterization of Cutaneous Oxalosis Mimicking Calciphylaxis: Diagnostic Pitfalls and Polarized Light Evaluation}},
author = {Shrina Patel and Brad Graham and Kaci Reaves and Mya Phelps},
journal = {Journal of Cutaneous Pathology},
year = {2026},
month = jul,
doi = {10.1111/cup.70177},
url = {https://doi.org/10.1111/cup.70177},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Histopathologic Characterization of Cutaneous Oxalosis Mimicking Calciphylaxis: Diagnostic Pitfalls and Polarized Light Evaluation
AU - Shrina Patel
AU - Brad Graham
AU - Kaci Reaves
AU - Mya Phelps
PY - 2026
DA - 2026/07/13
JO - Journal of Cutaneous Pathology
DO - 10.1111/cup.70177
UR - https://doi.org/10.1111/cup.70177
AB - Cutaneous oxalosis is an uncommon manifestation of primary hyperoxalosis, which can often resemble other cutaneous manifestations of end stage renal disease (ESRD), particularly calciphylaxis. We report the case of a 46 year old female with primary hyperoxaluria type one (PH1) believed to be well‐controlled on lumasiran, a small interfering ribonucleic acid therapy, which targets the mRNA responsible for producing hydroxyacid oxidase 1 (HAO1) and through reduction of this enzyme, decreases the hepatic overproduction of oxalate. The patient presented for dermatologic evaluation of presumed calciphylaxis. Repeated skin biopsies, however, confirmed cutaneous oxalosis despite perceived stable metabolic control with lumasiran. This case highlights the complexities and challenges in the diagnosis of cutaneous manifestations of chronic kidney disease and emphasizes the importance of histopathologic evaluation, even if the patient's primary hyperoxaluria is believed to be well‐controlled.
SN - 0303-6987
SN - 1600-0560
ER -