Peer-reviewedCC BYAnnals of clinical and translational neurology
Dynamic Changes in Serum Glial Fibrillary Acidic Protein Levels Predicts Early Neurological Deterioration After Intravenous Thrombolysis in Minor Stroke.
18 affiliations
- 1Stroke Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China.
- 2Department of Neurology, Songyuan Central Hospital, Songyuan, China.
- 3Department of Neurology, Jilin Neuropsychiatric Hospital, Siping, China.
- 4Stroke Center, Department of Neurology, Siping Central People's Hospital, Siping, China.
- 5Department of Neurology, Tonghua City Vascular Disease Hospital and Dongchang District People's Hospital, Tonghua, China.
- 6Department of Neurology, Songyuan Jilin Oilfield Hospital, Songyuan, China.
- 7Stroke Center, Department of Neurology, Dehuishi People's Hospital, Changchun, China.
- 8Department of Neurology, Affiliated Hospital of Jilin Medical College, Jilin, China.
- 9Department of Neurology, Songyuan Hospital of Integrated Traditional Chinese and Western Medicine, Songyuan, China.
- 10Stroke Center, Department of Neurology, Qianguoerros Mongolian Autonomous County Hospital, Songyuan, China.
- 11Department of Neurology, Jilin City Hospital of Chemical Industry, Jilin, China.
- 12Department of Neurology, Changchun People's Hospital, Changchun, China.
- 13Department of Neurology, Changchun Second Hospital, Changchun, China.
- 14Department of Neurology, Dongliao First People's Hospital, Liaoyuan, China.
- 15Department of Neurology, Jilin People's Hospital, Jilin, China.
- 16Department of Neurology, Jilin Province People's Hospital, Changchun, China.
- 17Stroke Center, Department of Neurology, Jilin Central General Hospital, Jilin, China.
- 18Neuroscience Research Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China.
Abstract
Objective
Minor strokes may be associated with early neurological deterioration (END) and disabilities. The objective was to investigate the role of serum glial fibrillary acidic protein (GFAP) levels in predicting END.Methods
Data originated from a multicenter cohort study conducted prospectively. ΔGFAP was calculated as the ratio of post-thrombolysis GFAP at 24 h to baseline GFAP. Univariable and multivariable binary logistic regression analyses were performed to assess the association between ∆GFAP and END, and a nomogram was established to illustrate its predictive value.Results
END occurred in 20 (7.35%) of the 272 patients with minor stroke who underwent intravenous thrombolysis (IVT). Elevated ∆GFAP was independently associated with END (OR, 3.50; 95% CI, 1.67 to 7.31; p < 0.001), even after adjusting for confounders (adjusted OR, 4.64; 95% CI, 1.86 to 11.54; p < 0.001). Furthermore, a model combining ∆GFAP, age, and National Institutes of Health Stroke Scale (NIHSS) score at admission demonstrated a good predictive value for END (AUC = 0.77; 95% CI, 0.67 to 0.89).Interpretation
∆GFAP is a strong, independent predictor of END in patients with minor strokes. Integrating ∆GFAP, age, and NIHSS score into a prognostic model results in a good discriminative ability for predicting END.
Related
- Gut microbiota-derived tryptophan metabolites and inflammatory factors enhance prediction of early neurological deterioration after intravenous thrombolysis in stroke patients: a comparative model study
- Correlation of TyG and NLR with early neurological deterioration after thrombolysis in patients with acute ischemic stroke
- Extending the Treatment Window for Intravenous Thrombolysis in Acute Ischemic Stroke
- Post-thrombolysis computed tomography angiography and perfusion features associated with an unfavorable early neurological response: a single-center retrospective study in a clinically selected anterior-circulation cohort
- Success rate and determinants of intravenous thrombolysis in acute ischemic stroke from the Malaysia National Stroke Registry
BibTeX
@article{zhou2026dynamic,
title = {{Dynamic Changes in Serum Glial Fibrillary Acidic Protein Levels Predicts Early Neurological Deterioration After Intravenous Thrombolysis in Minor Stroke.}},
author = {Jie Zhou and Yang Qu and Reziya Abuduxukuer and Peng Zhang and Ting Wang and Jian-Hua Gao and De-Wang Pan and Zhi-Mei Yuan and Chun-Ying Li and Li-Ping Chen and Jin-Hua Chen and Ji-Liang Gu and An-Ying Wang and Li-Gang Jiang and Liang Liu and Yong-Fei Jiang and Chun-Fei Wang and Yan Jia and Hong Xin and Chun-Li Jiang and Ying-Bin Qi and Xue-Feng Hu and Song Li and Hang Jin and Zhen-Ni Guo and Yi Yang and Biomarkers of Brain Injury Investigator Study Group},
journal = {Annals of clinical and translational neurology},
year = {2026},
month = oct,
doi = {10.1002/acn3.70552},
url = {https://europepmc.org/article/MED/42899785},
note = {CC BY},
}
RIS
TY - JOUR
TI - Dynamic Changes in Serum Glial Fibrillary Acidic Protein Levels Predicts Early Neurological Deterioration After Intravenous Thrombolysis in Minor Stroke.
AU - Jie Zhou
AU - Yang Qu
AU - Reziya Abuduxukuer
AU - Peng Zhang
AU - Ting Wang
AU - Jian-Hua Gao
AU - De-Wang Pan
AU - Zhi-Mei Yuan
AU - Chun-Ying Li
AU - Li-Ping Chen
AU - Jin-Hua Chen
AU - Ji-Liang Gu
AU - An-Ying Wang
AU - Li-Gang Jiang
AU - Liang Liu
AU - Yong-Fei Jiang
AU - Chun-Fei Wang
AU - Yan Jia
AU - Hong Xin
AU - Chun-Li Jiang
AU - Ying-Bin Qi
AU - Xue-Feng Hu
AU - Song Li
AU - Hang Jin
AU - Zhen-Ni Guo
AU - Yi Yang
AU - Biomarkers of Brain Injury Investigator Study Group
PY - 2026
DA - 2026/10/20
JO - Annals of clinical and translational neurology
DO - 10.1002/acn3.70552
UR - https://europepmc.org/article/MED/42899785
AB - Objective Minor strokes may be associated with early neurological deterioration (END) and disabilities. The objective was to investigate the role of serum glial fibrillary acidic protein (GFAP) levels in predicting END.Methods Data originated from a multicenter cohort study conducted prospectively. ΔGFAP was calculated as the ratio of post-thrombolysis GFAP at 24 h to baseline GFAP. Univariable and multivariable binary logistic regression analyses were performed to assess the association between ∆GFAP and END, and a nomogram was established to illustrate its predictive value.Results END occurred in 20 (7.35%) of the 272 patients with minor stroke who underwent intravenous thrombolysis (IVT). Elevated ∆GFAP was independently associated with END (OR, 3.50; 95% CI, 1.67 to 7.31; p < 0.001), even after adjusting for confounders (adjusted OR, 4.64; 95% CI, 1.86 to 11.54; p < 0.001). Furthermore, a model combining ∆GFAP, age, and National Institutes of Health Stroke Scale (NIHSS) score at admission demonstrated a good predictive value for END (AUC = 0.77; 95% CI, 0.67 to 0.89).Interpretation ∆GFAP is a strong, independent predictor of END in patients with minor strokes. Integrating ∆GFAP, age, and NIHSS score into a prognostic model results in a good discriminative ability for predicting END.
SN - 2328-9503
ER -