Development of 3D-Printed Photoreactors for Medicinal Chemistry Applications
- 1IQVIA Laboratories, Chesterford Research Park, Saffron Walden, United Kingdom, CB10 1XL
- 2School of Chemistry, University of Bristol, Cantock's Close, Bristol, United Kingdom, BS8 1TS
Abstract
3D-Printing has revolutionised the landscape of life sciences by enabling the rapid and affordable creation of bespoke equipment. The adaptation and design of light, cheap and easy to use photoredox reactors, where temperature control is introduced by compressed air flow, has allowed our laboratories to access a standardised and reproducible setup for all photoredox experiments. This work highlights the favourable comparison between these in-house 3D printed reactors and commercially available equipment across three industry-relevant transformations, decarboxylative sp2-sp3 coupling, cross-electrophile sp2-sp3 coupling and synthesis of aryl ethers. Furthermore, we report and share the design of a 3D-printed High Throughput Experimentation (HTE) box that enables rapid reaction optimisation, scoping and structure-activity relationship (SAR) generation in medicinal chemistry projects.
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BibTeX
@misc{sephton2026development,
title = {{Development of 3D-Printed Photoreactors for Medicinal Chemistry Applications}},
author = {Mark Sephton and Isabelle C. Ross and Piero Tardia and Alka Chauhan and Roberta Lanaro and Ryan Tinson and Thomas Levy and Grzegorz Pikus and Cole Clissold and Anthony J. Middleton and Thomas M. O’Brien and Alastair J. J. Lennox and Jacob S. Bestwick and Gabriele Fumagalli and Elisa Pasqua and John Ellard},
howpublished = {ChemRxiv},
year = {2026},
month = oct,
doi = {10.26434/chemrxiv.15010816/v1},
url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010816/v1},
note = {CC BY},
}
RIS
TY - UNPB
TI - Development of 3D-Printed Photoreactors for Medicinal Chemistry Applications
AU - Mark Sephton
AU - Isabelle C. Ross
AU - Piero Tardia
AU - Alka Chauhan
AU - Roberta Lanaro
AU - Ryan Tinson
AU - Thomas Levy
AU - Grzegorz Pikus
AU - Cole Clissold
AU - Anthony J. Middleton
AU - Thomas M. O’Brien
AU - Alastair J. J. Lennox
AU - Jacob S. Bestwick
AU - Gabriele Fumagalli
AU - Elisa Pasqua
AU - John Ellard
PY - 2026
DA - 2026/10/22
PB - ChemRxiv
DO - 10.26434/chemrxiv.15010816/v1
UR - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010816/v1
AB - 3D-Printing has revolutionised the landscape of life sciences by enabling the rapid and affordable creation of bespoke equipment. The adaptation and design of light, cheap and easy to use photoredox reactors, where temperature control is introduced by compressed air flow, has allowed our laboratories to access a standardised and reproducible setup for all photoredox experiments. This work highlights the favourable comparison between these in-house 3D printed reactors and commercially available equipment across three industry-relevant transformations, decarboxylative sp2-sp3 coupling, cross-electrophile sp2-sp3 coupling and synthesis of aryl ethers. Furthermore, we report and share the design of a 3D-printed High Throughput Experimentation (HTE) box that enables rapid reaction optimisation, scoping and structure-activity relationship (SAR) generation in medicinal chemistry projects.
ER -