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Peer-reviewedCC BY-NC-ND 4.0NPJ Parkinson's Disease

Supine hypertension as a distinct phenotype of neurogenic orthostatic hypotension with relatively preserved clinical function in Parkinson’s disease

  • Yihong Song1,2
  • Bo Shen1
  • Shuangshuang Dong1
  • Xiuxiu Hu1
  • Haiying Zhang1
  • Dongfeng Li1
  • Jun Zhu1
  • Xu Jiang1
  • Li Zhang1,3
  1. 1Department of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, China
  2. 2Department of Neurology, The First People’s Hospital of Lianyungang, Lianyungang, China
  3. 3Medical School, Nanjing University, Nanjing, China
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Abstract

Supine hypertension (SH) frequently co-occurs with neurogenic orthostatic hypotension (nOH) in Parkinson’s disease (PD), yet its clinical characteristics and autonomic status remain unclear. By comparing PD patients with coexisting nOH and SH against those with isolated nOH, we found that the PDOH + SH+ group displayed better cognitive function, lower burden of non-motor symptoms, and a higher quality of life. Notably, while patients with isolated nOH showed significant vagus nerve (VN) atrophy, the VN remained morphologically intact in patients with SH. These findings suggest that the presence of SH in patients with nOH denotes a distinct clinical phenotype of PD. Furthermore, this study provides valuable insights for addressing the therapeutic dilemma of managing PD OH and SH.

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Cite

BibTeXRIS
BibTeX
@article{song2026supine,
  title = {{Supine hypertension as a distinct phenotype of neurogenic orthostatic hypotension with relatively preserved clinical function in Parkinson’s disease}},
  author = {Yihong Song and Bo Shen and Shuangshuang Dong and Xiuxiu Hu and Haiying Zhang and Dongfeng Li and Jun Zhu and Xu Jiang and Li Zhang},
  journal = {NPJ Parkinson's Disease},
  year = {2026},
  month = jul,
  doi = {10.1038/s41531-026-01473-x},
  url = {https://doi.org/10.1038/s41531-026-01473-x},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Supine hypertension as a distinct phenotype of neurogenic orthostatic hypotension with relatively preserved clinical function in Parkinson’s disease
AU  - Yihong Song
AU  - Bo Shen
AU  - Shuangshuang Dong
AU  - Xiuxiu Hu
AU  - Haiying Zhang
AU  - Dongfeng Li
AU  - Jun Zhu
AU  - Xu Jiang
AU  - Li Zhang
PY  - 2026
DA  - 2026/07/10
JO  - NPJ Parkinson's Disease
DO  - 10.1038/s41531-026-01473-x
UR  - https://doi.org/10.1038/s41531-026-01473-x
AB  - Supine hypertension (SH) frequently co-occurs with neurogenic orthostatic hypotension (nOH) in Parkinson’s disease (PD), yet its clinical characteristics and autonomic status remain unclear. By comparing PD patients with coexisting nOH and SH against those with isolated nOH, we found that the PDOH + SH+ group displayed better cognitive function, lower burden of non-motor symptoms, and a higher quality of life. Notably, while patients with isolated nOH showed significant vagus nerve (VN) atrophy, the VN remained morphologically intact in patients with SH. These findings suggest that the presence of SH in patients with nOH denotes a distinct clinical phenotype of PD. Furthermore, this study provides valuable insights for addressing the therapeutic dilemma of managing PD OH and SH.
SN  - 2373-8057
ER  -