Atomoxetine for Orthostatic Hypotension in Traumatic and Non-traumatic Spinal Cord Injury: A Case Series From a Neuro-Rehabilitation Setting.
- 1Department of Neurological Rehabilitation, National Institute of Mental Health and Neuro Sciences, Bangalore, IND.
Abstract
Orthostatic hypotension (OH) following spinal cord injury (SCI) can significantly limit functional recovery by impairing participation in rehabilitation. Non-pharmacological techniques and pharmacological therapies, including fludrocortisone and midodrine, are conventionally used to manage OH. However, when these measures fail, atomoxetine has demonstrated benefit in other neurogenic OH populations. Evidence regarding the efficacy of this selective norepinephrine reuptake inhibitor is limited in neurogenic OH related to SCI. In this case series, we describe five patients with SCI who had symptomatic OH that did not respond to conventional pharmacological agents but showed clinical improvement with atomoxetine (dose range of 10 mg to 23 mg). Hence, atomoxetine can be considered a potential alternative therapeutic option for OH related to SCI in patients with OH refractory to conventional management.
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BibTeX
@article{prakash2026atomoxetine,
title = {{Atomoxetine for Orthostatic Hypotension in Traumatic and Non-traumatic Spinal Cord Injury: A Case Series From a Neuro-Rehabilitation Setting.}},
author = {Navin B Prakash and Shaneena Pavithran and Anupam Gupta and Meeka Khanna},
journal = {Cureus},
year = {2026},
month = sep,
doi = {10.7759/cureus.116985},
url = {https://europepmc.org/article/MED/42947985},
note = {CC BY},
}
RIS
TY - JOUR
TI - Atomoxetine for Orthostatic Hypotension in Traumatic and Non-traumatic Spinal Cord Injury: A Case Series From a Neuro-Rehabilitation Setting.
AU - Navin B Prakash
AU - Shaneena Pavithran
AU - Anupam Gupta
AU - Meeka Khanna
PY - 2026
DA - 2026/09/26
JO - Cureus
DO - 10.7759/cureus.116985
UR - https://europepmc.org/article/MED/42947985
AB - Orthostatic hypotension (OH) following spinal cord injury (SCI) can significantly limit functional recovery by impairing participation in rehabilitation. Non-pharmacological techniques and pharmacological therapies, including fludrocortisone and midodrine, are conventionally used to manage OH. However, when these measures fail, atomoxetine has demonstrated benefit in other neurogenic OH populations. Evidence regarding the efficacy of this selective norepinephrine reuptake inhibitor is limited in neurogenic OH related to SCI. In this case series, we describe five patients with SCI who had symptomatic OH that did not respond to conventional pharmacological agents but showed clinical improvement with atomoxetine (dose range of 10 mg to 23 mg). Hence, atomoxetine can be considered a potential alternative therapeutic option for OH related to SCI in patients with OH refractory to conventional management.
SN - 2168-8184
ER -