Prevalence of rifampicin-resistant tuberculosis and its associated factors among patients with tuberculosis at Galkayo General Hospital, Puntland, Somalia: a facility-based cross-sectional study.
7 affiliations
- 1Department of Pharmacy, Puntland State University, Puntland, Somalia.
- 2Department of Clinical Pharmacy, School of Pharmacy, College of Health and Medical Science, Haramaya University, Harar, Ethiopia.
- 3Department of Social and Administrative Pharmacy, School of Pharmacy, College of Health and Medical Science, Haramaya University, Harar, Ethiopia.
- 4Department of National Tuberculosis Program, Ministry of Health, Puntland, Somalia.
- 5Department of Epidemiology, School of Public Health, College of Health and Medical Sciences, East Africa University, Qardho, Somalia.
- 6Department of Epidemiology and Biostatistics, School of Public Health, College of Health and Medical Science, Haramaya University, Harar, Ethiopia.
- 7Department of Pharmacology, School of Pharmacy, College of Health and Medical Science, Haramaya University, Harar, Ethiopia.
Abstract
drug-resistant tuberculosis (TB) remains a major public health challenge globally. Monitoring its prevalence and associated factors is essential for effective control strategies. The current study aimed to assess the burden of rifampicin-resistant TB (RR-TB) and its associated factors among patients with TB at Galkayo General Hospital, Puntland, Somalia. a facility-based cross-sectional study was conducted using medical records of patients with TB registered from January 2020 to December 2024. Of 422 randomly reviewed records, 410 with complete data were included in the analysis. Descriptive statistics were used to summarize patient details. Univariate and multivariable logistic regression analyses were used to identify variables associated with RR-TB. Adjusted odds ratios (aOR) with 95% confidence intervals (CIs) were reported. A p-value <.05 was deemed statistically significant. the mean age of participants was 29.9 ± 20.6 years, and 64.6% were male. The prevalence of RR-TB was 9.02% (37/410: 95% CI 6.43%-12.22%). In multivariable logistic analysis, having a history of close contact with a patient with TB (aOR: 2.43, 95% CI 1.13-5.21; P=.02), previous history of TB (aOR: 3.63, 95% CI 1.72-7.67; P<.001), and treatment failure (aOR: 9.03, 95% CI 2.03-40.12; P<.01) were strongly associated with RR-TB. rifampicin-resistant tuberculosis represents a substantial burden among patients with TB in Galkayo General Hospital. Close contact with TB cases, previous TB history, and treatment failure were significant predictors of RR-TB.
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BibTeX
@article{mohamud2026prevalence,
title = {{Prevalence of rifampicin-resistant tuberculosis and its associated factors among patients with tuberculosis at Galkayo General Hospital, Puntland, Somalia: a facility-based cross-sectional study.}},
author = {Hawo Mohamud and Kirubel Minsamo Mishore and Bisrat Hagos and Farah Said Barre and Asia Mohammed Ahmed and Tewodros Assefa and Abera Jambo and Assefa Tola and Abraham Nigussie Mekuria},
journal = {The Pan African medical journal},
year = {2026},
month = jun,
doi = {10.11604/pamj.2026.54.34.51751},
url = {https://europepmc.org/article/MED/42953038},
note = {CC BY},
}
RIS
TY - JOUR
TI - Prevalence of rifampicin-resistant tuberculosis and its associated factors among patients with tuberculosis at Galkayo General Hospital, Puntland, Somalia: a facility-based cross-sectional study.
AU - Hawo Mohamud
AU - Kirubel Minsamo Mishore
AU - Bisrat Hagos
AU - Farah Said Barre
AU - Asia Mohammed Ahmed
AU - Tewodros Assefa
AU - Abera Jambo
AU - Assefa Tola
AU - Abraham Nigussie Mekuria
PY - 2026
DA - 2026/06/08
JO - The Pan African medical journal
DO - 10.11604/pamj.2026.54.34.51751
UR - https://europepmc.org/article/MED/42953038
AB - drug-resistant tuberculosis (TB) remains a major public health challenge globally. Monitoring its prevalence and associated factors is essential for effective control strategies. The current study aimed to assess the burden of rifampicin-resistant TB (RR-TB) and its associated factors among patients with TB at Galkayo General Hospital, Puntland, Somalia. a facility-based cross-sectional study was conducted using medical records of patients with TB registered from January 2020 to December 2024. Of 422 randomly reviewed records, 410 with complete data were included in the analysis. Descriptive statistics were used to summarize patient details. Univariate and multivariable logistic regression analyses were used to identify variables associated with RR-TB. Adjusted odds ratios (aOR) with 95% confidence intervals (CIs) were reported. A p-value <.05 was deemed statistically significant. the mean age of participants was 29.9 ± 20.6 years, and 64.6% were male. The prevalence of RR-TB was 9.02% (37/410: 95% CI 6.43%-12.22%). In multivariable logistic analysis, having a history of close contact with a patient with TB (aOR: 2.43, 95% CI 1.13-5.21; P=.02), previous history of TB (aOR: 3.63, 95% CI 1.72-7.67; P<.001), and treatment failure (aOR: 9.03, 95% CI 2.03-40.12; P<.01) were strongly associated with RR-TB. rifampicin-resistant tuberculosis represents a substantial burden among patients with TB in Galkayo General Hospital. Close contact with TB cases, previous TB history, and treatment failure were significant predictors of RR-TB.
SN - 1937-8688
ER -