Myxobacterial terpene synthases produce structurally diverse sesquiterpenes

Abstract

Myxobacteria represent an underexplored source of terpenoids with relatively few terpenoids and terpene synthases known from this phylum. Thirteen sesquiterpenes (1–13) representing ten distinct carbon skeletons were identified from eight myxobacterial terpene synthases. Twelve of these natural products (1–10, 12, and 13), including enantiomers of known brasilane-type sesquiterpenes (1–3) and the humulene analog viticumulin A (4), were previously unknown from myxobacteria. Moreover, ten (i.e., 1–4, 7–10, 12, 13) have not been previously reported from bacterial sources. These data demonstrate that myxobacteria represent a rich and largely untapped reservoir of terpenoids that should be further investigated.

Hidden Diversity in Myxobacterial Lasso Peptides: An Atypical RiPP Recognition Element and Host-Mediated Loss of the Lasso Tail
Asfandyar Sikandar, Haowen Zhao, Guangyi Chen +4
ChemRxiv22 Sep 2026PreprintCC BY-NC-NDFull textPharmacology & toxicologyChemRxiv
Enhancing ferric-reducing antioxidant activity through terpene mixture optimization
Ahmed Qasem
Scientific Reports25 Oct 2026Peer-reviewedCC BY 4.0Full textGeneral medicineCrossref
Pilot study of a local exhaust ventilation system to control particle and terpene concentrations during cannabis processing
Callan Krevanko, Charlotte Beatson, Martin Cohen +2
Frontiers in Public Health23 Oct 2026Peer-reviewedCC BY 4.0Full textEpidemiology & public healthCrossrefDOAJ
“I don't have to choose between everything”: Self-reported fruit and vegetable affordability, purchasing shifts, and healthcare utilization among produce prescription program participants in North Carolina
Alexandria E. Reimold, Jess Ostrowski, Amy Shi-nan Feng +4
Preventive medicine reports25 Sep 2026Peer-reviewedCC BY-NCFull textGeneral medicineEurope PMC
Explained and Residual Variability of the Fetal Mechanical PR Interval in Structurally Normal Hearts: A Secondary Analysis of Physiological, Biometric, and Doppler Covariates
Jakub Mlodawski, Katarzyna Janiak, Lukasz Pawlik +3
Biomedicines1 Oct 2026Peer-reviewedCC BYFull textGeneral medicineEurope PMC

Cite

BibTeX RIS

BibTeX

@misc{ahmed2026myxobacterial,
  title = {{Myxobacterial terpene synthases produce structurally diverse sesquiterpenes}},
  author = {Mohammed M. A. Ahmed and Jordan Lauer-Fields and Jordan Nafie and Evans Gyapong and Jeffrey D. Rudolf},
  howpublished = {ChemRxiv},
  year = {2026},
  month = oct,
  doi = {10.26434/chemrxiv.15010682/v1},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010682/v1},
  note = {CC BY-NC-ND},
}

RIS

TY  - UNPB
TI  - Myxobacterial terpene synthases produce structurally diverse sesquiterpenes
AU  - Mohammed M. A. Ahmed
AU  - Jordan Lauer-Fields
AU  - Jordan Nafie
AU  - Evans Gyapong
AU  - Jeffrey D. Rudolf
PY  - 2026
DA  - 2026/10/19
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15010682/v1
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010682/v1
AB  - Myxobacteria represent an underexplored source of terpenoids with relatively few terpenoids and terpene synthases known from this phylum. Thirteen sesquiterpenes (1–13) representing ten distinct carbon skeletons were identified from eight myxobacterial terpene synthases. Twelve of these natural products (1–10, 12, and 13), including enantiomers of known brasilane-type sesquiterpenes (1–3) and the humulene analog viticumulin A (4), were previously unknown from myxobacteria. Moreover, ten (i.e., 1–4, 7–10, 12, 13) have not been previously reported from bacterial sources. These data demonstrate that myxobacteria represent a rich and largely untapped reservoir of terpenoids that should be further investigated.
ER  -

Abstract

Related

Cite