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Peer-reviewedCC BYCell Reports

Prophage induction contributes to alterations in the gut phageome during intestinal inflammation

  • Anshul Sinha1,2
  • Amy Qian3,4
  • Tommy Boutin5,2
  • Corinne F. Maurice6,2
6 affiliations
  1. 1Department of Microbiology & Immunology, McGill University, Montréal, QC, Canada; McGill Centre for Microbiome Research, Montréal, QC, Canada. Electronic address: [email protected]
  2. 2McGill University
  3. 3Department of Microbiology & Immunology, McGill University, Montréal, QC, Canada; Department of Experimental Medicine, University of Toronto, Toronto, ON, Canada
  4. 4University of Toronto, McGill University
  5. 5Department of Microbiology & Immunology, McGill University, Montréal, QC, Canada
  6. 6Department of Microbiology & Immunology, McGill University, Montréal, QC, Canada; McGill Centre for Microbiome Research, Montréal, QC, Canada. Electronic address: [email protected]
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Abstract

Bacteriophages (phages) are abundant members of the gut microbiota and regulators of bacterial communities. During homeostasis, gut phage communities are longitudinally stable and lysogenic replication is dominant. In chronic gut inflammatory disorders, such as inflammatory bowel diseases (IBDs), there are alterations in phage diversity, which may result from changes in phage replication cycles. Here, we use a combination of in vitro, simplified community, and whole-community bioinformatics approaches to investigate whether prophage induction contributes to these alterations. We identify several compounds associated with gut inflammation that induce prophages from commensal gut bacterial isolates. Analyzing data from two mouse models of colitis, we observe that shifts in the composition of temperate phages occur over the course of inflammation, supporting a switch from lysogenic to lytic replication. Collectively, our observations support the idea that prophage induction contributes to alterations in the phageome associated with intestinal inflammation.

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Cite

BibTeXRIS
BibTeX
@article{sinha2026prophage,
  title = {{Prophage induction contributes to alterations in the gut phageome during intestinal inflammation}},
  author = {Anshul Sinha and Amy Qian and Tommy Boutin and Corinne F. Maurice},
  journal = {Cell Reports},
  year = {2026},
  month = jun,
  doi = {10.1016/j.celrep.2026.117491},
  url = {https://doi.org/10.1016/j.celrep.2026.117491},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Prophage induction contributes to alterations in the gut phageome during intestinal inflammation
AU  - Anshul Sinha
AU  - Amy Qian
AU  - Tommy Boutin
AU  - Corinne F. Maurice
PY  - 2026
DA  - 2026/06/19
JO  - Cell Reports
DO  - 10.1016/j.celrep.2026.117491
UR  - https://doi.org/10.1016/j.celrep.2026.117491
AB  - Bacteriophages (phages) are abundant members of the gut microbiota and regulators of bacterial communities. During homeostasis, gut phage communities are longitudinally stable and lysogenic replication is dominant. In chronic gut inflammatory disorders, such as inflammatory bowel diseases (IBDs), there are alterations in phage diversity, which may result from changes in phage replication cycles. Here, we use a combination of in vitro, simplified community, and whole-community bioinformatics approaches to investigate whether prophage induction contributes to these alterations. We identify several compounds associated with gut inflammation that induce prophages from commensal gut bacterial isolates. Analyzing data from two mouse models of colitis, we observe that shifts in the composition of temperate phages occur over the course of inflammation, supporting a switch from lysogenic to lytic replication. Collectively, our observations support the idea that prophage induction contributes to alterations in the phageome associated with intestinal inflammation.
SN  - 2211-1247
SN  - 2639-1856
ER  -