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Peer-reviewedCC BY 4.0International Journal of Molecular Sciences

Natural Capnosanes: Chemical Structures and Bioactivities

  • Szu-Yin Yu1
  • Yi-Hao Lo2,3
  • Wei-Chiung Chi4
  • Yue-Wen Chuang5,6
  • Yun-Ting Zeng5,6
  • Li-Guo Zheng6
  • Su-Ying Chien7
  • Hsi-Wen Sun8
  • Yueh-Wen Liu9
  • Kuang-Nan Tsai10
  • Zhi-Hong Wen5,6
  • Yu-Chi Tsai11
1 more authors
  • Ping-Jyun Sung1,5,6,12,13,14,15,16
16 affiliations
  1. 1Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807378, Taiwan
  2. 2Department of Family Medicine, Zuoying Armed Forces General Hospital, Kaohsiung 813204, Taiwan
  3. 3Department of Nursing, Meiho University, Pingtung 912009, Taiwan
  4. 4Department of Food Science, National Quemoy University, Kinmen 892009, Taiwan
  5. 5Department of Marine Biotechnology & Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan
  6. 6National Museum of Marine Biology & Aquarium, Pingtung 944401, Taiwan
  7. 7X-Ray Laboratory, Institute of Chemistry, Academia Sinica, Taipei 115201, Taiwan
  8. 8Department of Chemical Engineering and Biotechnology, Institute of Biochemical and Biomedical Engineering, National Taipei University of Technology, Taipei 106344, Taiwan
  9. 9Department of Cosmetics and Fashion Styling, Cheng Shiu University, Kaohsiung 833301, Taiwan
  10. 10Department of Beauty Science, Meiho University, Pingtung 912009, Taiwan
  11. 11School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 404328, Taiwan
  12. 12Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404394, Taiwan
  13. 13Ph.D. Program in Pharmaceutical Biotechnology, Fu Jen Catholic University, New Taipei City 242062, Taiwan
  14. 14Department of Biochemistry and Molecular Medicine, National Dong Hwa University, Hualien 974301, Taiwan
  15. 15School of Medicine, Kaohsiung Medical University, Kaohsiung 807378, Taiwan
  16. 16Institute of Marine Ecology and Conservation, National Sun Yat-sen University, Kaohsiung 804201, Taiwan
Open at sourceDOICite

Abstract

This review provides a comprehensive overview of the structural characteristics, nomenclature, and biological activities of naturally occurring capnosane diterpenoids (3,7-cyclized cembranoids) reported from 1986 to 2025. The compounds covered in this survey have been isolated primarily from octocorals of the genera Alcyonium, Cespitularia, Klyxum, Lobophytum, Sarcophyton, and Sclerophytum, as well as from the tobacco species Nicotiana tabacum. A number of these naturally derived metabolites have demonstrated noteworthy biomedical potential in various biological evaluations.

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Cite

BibTeXRIS
BibTeX
@article{yu2026natural,
  title = {{Natural Capnosanes: Chemical Structures and Bioactivities}},
  author = {Szu-Yin Yu and Yi-Hao Lo and Wei-Chiung Chi and Yue-Wen Chuang and Yun-Ting Zeng and Li-Guo Zheng and Su-Ying Chien and Hsi-Wen Sun and Yueh-Wen Liu and Kuang-Nan Tsai and Zhi-Hong Wen and Yu-Chi Tsai and Ping-Jyun Sung},
  journal = {International Journal of Molecular Sciences},
  year = {2026},
  month = nov,
  doi = {10.3390/ijms27219808},
  url = {https://www.mdpi.com/1422-0067/27/21/9808},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Natural Capnosanes: Chemical Structures and Bioactivities
AU  - Szu-Yin Yu
AU  - Yi-Hao Lo
AU  - Wei-Chiung Chi
AU  - Yue-Wen Chuang
AU  - Yun-Ting Zeng
AU  - Li-Guo Zheng
AU  - Su-Ying Chien
AU  - Hsi-Wen Sun
AU  - Yueh-Wen Liu
AU  - Kuang-Nan Tsai
AU  - Zhi-Hong Wen
AU  - Yu-Chi Tsai
AU  - Ping-Jyun Sung
PY  - 2026
DA  - 2026/11/01
JO  - International Journal of Molecular Sciences
DO  - 10.3390/ijms27219808
UR  - https://www.mdpi.com/1422-0067/27/21/9808
AB  - This review provides a comprehensive overview of the structural characteristics, nomenclature, and biological activities of naturally occurring capnosane diterpenoids (3,7-cyclized cembranoids) reported from 1986 to 2025. The compounds covered in this survey have been isolated primarily from octocorals of the genera Alcyonium, Cespitularia, Klyxum, Lobophytum, Sarcophyton, and Sclerophytum, as well as from the tobacco species Nicotiana tabacum. A number of these naturally derived metabolites have demonstrated noteworthy biomedical potential in various biological evaluations.
SN  - 1422-0067
ER  -