Giant hypervascular atypical lipomatous tumor/well-differentiated liposarcoma of the cervicodorsal region: a case report
- 1Department of Burns and Plastic Surgery, North Sichuan Medical College, School of Clinical Medicine, Nanchong, Sichuan, China
- 2Department of Burns and Plastic Surgery, West China School of Medicine, Sichuan University, Sichuan University Affiliated Chengdu Second People’s Hospital, Chengdu Second People’s Hospital, Chengdu, Sichuan, China
- 3Department of Medical Cosmetology, West China School of Medicine, Sichuan University, Sichuan University Affiliated Chengdu Second People’s Hospital, Chengdu Second People’s Hospital, Chengdu, Sichuan, China
Abstract
We report a case of giant hypervascular atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDLPS) of the cervicodorsal region in a 62-year-old man. The mass had enlarged slowly over 17 years, with accelerated growth during the preceding 2 years accompanied by a local skin pulling sensation, but without definite airway, neurologic, or major vascular compression. Preoperative computed tomography angiography (CTA) demonstrated a lesion of approximately 20.9 cm × 28.6 cm × 25.4 cm containing internal septa, nodular components, and marked vascularity supplied predominantly by branches of both subclavian arteries. The patient underwent en bloc tumor excision with local advancement flap reconstruction; the resected specimen weighed approximately 6.01 kg, the resulting defect measured approximately 15 cm × 11 cm, the operative time was nearly 6 h, and the estimated blood loss was approximately 700 mL. Postoperative pathology showed focal spindle-cell proliferation with myxoid change and, together with the MDM2, CDK4, and p16 positivity documented in the pathology report, supported the diagnosis of ALT/WDLPS. At short-term follow-up, the incision and flaps had healed well, with no definite local recurrence. This case indicates that a long-standing, slowly enlarging giant lipomatous mass in the cervicodorsal region should not be excluded from the diagnosis of ALT/WDLPS solely on the basis of indolent clinical behavior. When a lesion is very large or imaging suggests rich vascularity, preoperative vascular assessment, hemostatic contingency planning, and simultaneous wound reconstruction design should be incorporated into the surgical plan.
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BibTeX
@article{liao2026giant,
title = {{Giant hypervascular atypical lipomatous tumor/well-differentiated liposarcoma of the cervicodorsal region: a case report}},
author = {Zhonghai Liao and Feng Qin and Song Wang and Xinyu Wan and Hong Li},
journal = {Frontiers in Medicine},
year = {2026},
month = oct,
doi = {10.3389/fmed.2026.1925841},
url = {https://doi.org/10.3389/fmed.2026.1925841},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Giant hypervascular atypical lipomatous tumor/well-differentiated liposarcoma of the cervicodorsal region: a case report
AU - Zhonghai Liao
AU - Feng Qin
AU - Song Wang
AU - Xinyu Wan
AU - Hong Li
PY - 2026
DA - 2026/10/21
JO - Frontiers in Medicine
DO - 10.3389/fmed.2026.1925841
UR - https://doi.org/10.3389/fmed.2026.1925841
AB - We report a case of giant hypervascular atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDLPS) of the cervicodorsal region in a 62-year-old man. The mass had enlarged slowly over 17 years, with accelerated growth during the preceding 2 years accompanied by a local skin pulling sensation, but without definite airway, neurologic, or major vascular compression. Preoperative computed tomography angiography (CTA) demonstrated a lesion of approximately 20.9 cm × 28.6 cm × 25.4 cm containing internal septa, nodular components, and marked vascularity supplied predominantly by branches of both subclavian arteries. The patient underwent en bloc tumor excision with local advancement flap reconstruction; the resected specimen weighed approximately 6.01 kg, the resulting defect measured approximately 15 cm × 11 cm, the operative time was nearly 6 h, and the estimated blood loss was approximately 700 mL. Postoperative pathology showed focal spindle-cell proliferation with myxoid change and, together with the MDM2, CDK4, and p16 positivity documented in the pathology report, supported the diagnosis of ALT/WDLPS. At short-term follow-up, the incision and flaps had healed well, with no definite local recurrence. This case indicates that a long-standing, slowly enlarging giant lipomatous mass in the cervicodorsal region should not be excluded from the diagnosis of ALT/WDLPS solely on the basis of indolent clinical behavior. When a lesion is very large or imaging suggests rich vascularity, preoperative vascular assessment, hemostatic contingency planning, and simultaneous wound reconstruction design should be incorporated into the surgical plan.
SN - 2296-858X
ER -