Recurrent angiolipoma-like atypical lipomatous tumour
- 1Department of Anatomical Pathology; Corresponding author.
- 2Mount Elizabeth Orchard Hospital, Singapore
- 3Department of Anatomical Pathology
Abstract
Angiolipoma is a benign lipomatous tumour composed of mature fat cells interspersed with small and thin-walled blood vessels, some of which contain fibrin thrombi. Atypical lipomatous tumour / well-differentiated liposarcoma is a locally aggressive lipomatous neoplasm showing at least focal nuclear atypia in the adipocytes and stromal cells. MDM2 and/or CDK4 amplification is almost always present. A 70 year old woman presented with a recurrent lipomatous tumour in the posterior thigh which was steadily enlarging in size. It measured 14.5 × 9.5 × 5 cm. Microscopic examination showed that the tumour was composed of mature adipocytes with clusters of small, thin-walled blood vessels, resembling an angiolipoma. Intravascular fibrin thrombi were present. There were scattered atypical stromal cells with enlarged, hyperchromatic and pleomorphic nuclei and occasional multinucleation. The endothelial cells lining the blood vessels did not show atypia. MDM2 amplification was detected by FISH. She was diagnosed with atypical lipomatous tumour. There was no recurrence after excision at one year follow up. An atypical lipomatous tumour / well-differentiated liposarcoma that also demonstrates clusters of small, thin-walled blood vessels resembling an angiolipoma is rare. To the best of our knowledge, there has only been one reported case of angiolipoma-like atypical lipomatous tumour/well-differentiated liposarcoma in literature.
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BibTeX
@article{tan2026recurrent,
title = {{Recurrent angiolipoma-like atypical lipomatous tumour}},
author = {Joey Yan Leng Tan and Siang Shen Leon Foo and Kesavan Sittampalam},
journal = {Human Pathology Reports},
year = {2026},
month = oct,
doi = {10.1016/j.hpr.2026.300855},
url = {https://doi.org/10.1016/j.hpr.2026.300855},
note = {CC BY},
}
RIS
TY - JOUR
TI - Recurrent angiolipoma-like atypical lipomatous tumour
AU - Joey Yan Leng Tan
AU - Siang Shen Leon Foo
AU - Kesavan Sittampalam
PY - 2026
DA - 2026/10/30
JO - Human Pathology Reports
DO - 10.1016/j.hpr.2026.300855
UR - https://doi.org/10.1016/j.hpr.2026.300855
AB - Angiolipoma is a benign lipomatous tumour composed of mature fat cells interspersed with small and thin-walled blood vessels, some of which contain fibrin thrombi. Atypical lipomatous tumour / well-differentiated liposarcoma is a locally aggressive lipomatous neoplasm showing at least focal nuclear atypia in the adipocytes and stromal cells. MDM2 and/or CDK4 amplification is almost always present. A 70 year old woman presented with a recurrent lipomatous tumour in the posterior thigh which was steadily enlarging in size. It measured 14.5 × 9.5 × 5 cm. Microscopic examination showed that the tumour was composed of mature adipocytes with clusters of small, thin-walled blood vessels, resembling an angiolipoma. Intravascular fibrin thrombi were present. There were scattered atypical stromal cells with enlarged, hyperchromatic and pleomorphic nuclei and occasional multinucleation. The endothelial cells lining the blood vessels did not show atypia. MDM2 amplification was detected by FISH. She was diagnosed with atypical lipomatous tumour. There was no recurrence after excision at one year follow up. An atypical lipomatous tumour / well-differentiated liposarcoma that also demonstrates clusters of small, thin-walled blood vessels resembling an angiolipoma is rare. To the best of our knowledge, there has only been one reported case of angiolipoma-like atypical lipomatous tumour/well-differentiated liposarcoma in literature.
SN - 2772-736X
ER -