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PreprintCC BYmedRxiv

Peripheral Blood NADP(H) Redox Metabolism in Alzheimers Disease and Mild Cognitive Impairment: A Systematic Review and Meta-analysis Where Feasible

  • D. Zhong
  • D. He
  • J. Chen
  • c. yangyang1
  1. 1Department of Neurology, Guangyuan First People's Hospital
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Abstract

Background: The reduced and oxidized forms of nicotinamide adenine dinucleotide phosphate (NADPH/NADP) connect cellular reducing power with the glutathione and thioredoxin systems. Peripheral alterations in this network may reflect systemic redox dysregulation in Alzheimer s disease (AD) and mild cognitive impairment (MCI), but the evidence has not been quantitatively synthesized. Objective: To systematically evaluate peripheral blood NADP(H) redox metabolism and related enzymes in AD and MCI and to perform meta analyses when the available data were sufficiently comparable.

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Cite

BibTeXRIS
BibTeX
@misc{zhong2026peripheral,
  title = {{Peripheral Blood NADP(H) Redox Metabolism in Alzheimers Disease and Mild Cognitive Impairment: A Systematic Review and Meta-analysis Where Feasible}},
  author = {D. Zhong and D. He and J. Chen and c. yangyang},
  howpublished = {medRxiv},
  year = {2026},
  month = nov,
  doi = {10.64898/2026.11.09.26367672},
  url = {https://www.medrxiv.org/content/10.64898/2026.11.09.26367672v1},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - Peripheral Blood NADP(H) Redox Metabolism in Alzheimers Disease and Mild Cognitive Impairment: A Systematic Review and Meta-analysis Where Feasible
AU  - D. Zhong
AU  - D. He
AU  - J. Chen
AU  - c. yangyang
PY  - 2026
DA  - 2026/11/09
PB  - medRxiv
DO  - 10.64898/2026.11.09.26367672
UR  - https://www.medrxiv.org/content/10.64898/2026.11.09.26367672v1
AB  - Background: The reduced and oxidized forms of nicotinamide adenine dinucleotide phosphate (NADPH/NADP) connect cellular reducing power with the glutathione and thioredoxin systems. Peripheral alterations in this network may reflect systemic redox dysregulation in Alzheimer s disease (AD) and mild cognitive impairment (MCI), but the evidence has not been quantitatively synthesized. Objective: To systematically evaluate peripheral blood NADP(H) redox metabolism and related enzymes in AD and MCI and to perform meta analyses when the available data were sufficiently comparable.
ER  -