Radiation-induced meningioma and high-grade glioma following craniospinal irradiation for medulloblastoma: a case report.
- 1Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, United States.
- 2Department of Pathology, Thomas Jefferson University, Philadelphia, PA, United States.
Abstract
Background
Cranial irradiation is known to carry the risk of late intracranial toxicities, most notably the development of secondary intracranial neoplasms. Both meningiomas and gliomas can develop as radiation-induced tumors. Radiation-induced meningiomas represent the most common secondary tumor in patients who have previously undergone cranial irradiation. Secondary gliomas are the second most common secondary tumor in patients with prior cranial radiation.Case description
We present the case of a patient with a history of medulloblastoma who received craniospinal irradiation at the age of 29 years. She remained disease-free for nearly two decades until developing an occipital meningioma at the age of 53, which recurred despite surgery and radiotherapy. Eight years later, she was diagnosed with a high-grade astrocytic neoplasm within the prior radiation field. Despite additional treatment, her disease rapidly progressed, and she expired.Conclusion
This case highlights the late oncogenic risk associated with prior cranial irradiation in long-term survivors and emphasizes the necessity of lifelong clinical and radiographic surveillance. Uniquely, the patient developed two distinct radiation-induced neoplasms, suggesting heterogeneous secondary tumorigenesis following radiation exposure.
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BibTeX
@article{carey2026radiationinduced,
title = {{Radiation-induced meningioma and high-grade glioma following craniospinal irradiation for medulloblastoma: a case report.}},
author = {Kelsey Carey and Violet Quann and Wenyin Shi and Mark Curtis},
journal = {Surgical neurology international},
year = {2026},
month = oct,
doi = {10.25259/sni_137_2026},
url = {https://europepmc.org/article/MED/42974223},
note = {CC BY-NC-SA},
}
RIS
TY - JOUR
TI - Radiation-induced meningioma and high-grade glioma following craniospinal irradiation for medulloblastoma: a case report.
AU - Kelsey Carey
AU - Violet Quann
AU - Wenyin Shi
AU - Mark Curtis
PY - 2026
DA - 2026/10/16
JO - Surgical neurology international
DO - 10.25259/sni_137_2026
UR - https://europepmc.org/article/MED/42974223
AB - Background Cranial irradiation is known to carry the risk of late intracranial toxicities, most notably the development of secondary intracranial neoplasms. Both meningiomas and gliomas can develop as radiation-induced tumors. Radiation-induced meningiomas represent the most common secondary tumor in patients who have previously undergone cranial irradiation. Secondary gliomas are the second most common secondary tumor in patients with prior cranial radiation.Case description We present the case of a patient with a history of medulloblastoma who received craniospinal irradiation at the age of 29 years. She remained disease-free for nearly two decades until developing an occipital meningioma at the age of 53, which recurred despite surgery and radiotherapy. Eight years later, she was diagnosed with a high-grade astrocytic neoplasm within the prior radiation field. Despite additional treatment, her disease rapidly progressed, and she expired.Conclusion This case highlights the late oncogenic risk associated with prior cranial irradiation in long-term survivors and emphasizes the necessity of lifelong clinical and radiographic surveillance. Uniquely, the patient developed two distinct radiation-induced neoplasms, suggesting heterogeneous secondary tumorigenesis following radiation exposure.
SN - 2229-5097
SN - 2152-7806
ER -