Synthesis, characterization and biological evaluation of newly designed silver(I)-N-heterocyclic carbene (NHC) complexes
Abstract
MRI technology continues to advance, increasing the demand for reliable tools for system testing, validation, and training. Although human subjects remain the gold standard, their use is constrained by ethical considerations, cost, and limited reproducibility. Consequently, there is a growing need for anatomically realistic MRI phantoms that support research, development, and education. Many existing MRI phantoms emphasize quantitative relaxation properties but remain structurally simplistic, lacking anatomical complexity and clinically relevant relative contrast. This technical note presents a practical workflow for developing high-fidelity cross-sectional MRI phantoms of the head, knee, hip, and abdomen. Representative MRI slices were manually delineated, converted into computer-aided design models, and fabricated using 3D printing. The resulting hollow structures were filled with contrast-enhanced gel-based tissue-mimicking materials. MRI acquisitions were performed to assess anatomical representation and relative tissue contrast. The proposed methodology demonstrates a low-cost and accessible approach for producing anatomically realistic MRI phantoms suitable for research, protocol development, and teaching. The workflow is adaptable and can be extended to other anatomical regions.
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BibTeX
@article{abdelmalek2026synthesis,
title = {{Synthesis, characterization and biological evaluation of newly designed silver(I)-N-heterocyclic carbene (NHC) complexes}},
author = {Dorra Abdelmalek and Neslihan Şahin and Bui Minh Thu Ly and İsmail Özdemir and Kawther Bedchich and Salim Kraiem and Mohamed Ali Mosrati and Nour Louati and Sami Aifa and David Sémeril},
journal = {Results in Chemistry},
year = {2026},
month = oct,
doi = {10.1016/j.rechem.2026.103400},
url = {https://hal.science/hal-05805662v1},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Synthesis, characterization and biological evaluation of newly designed silver(I)-N-heterocyclic carbene (NHC) complexes
AU - Dorra Abdelmalek
AU - Neslihan Şahin
AU - Bui Minh Thu Ly
AU - İsmail Özdemir
AU - Kawther Bedchich
AU - Salim Kraiem
AU - Mohamed Ali Mosrati
AU - Nour Louati
AU - Sami Aifa
AU - David Sémeril
PY - 2026
DA - 2026/10/19
JO - Results in Chemistry
DO - 10.1016/j.rechem.2026.103400
UR - https://hal.science/hal-05805662v1
AB - MRI technology continues to advance, increasing the demand for reliable tools for system testing, validation, and training. Although human subjects remain the gold standard, their use is constrained by ethical considerations, cost, and limited reproducibility. Consequently, there is a growing need for anatomically realistic MRI phantoms that support research, development, and education. Many existing MRI phantoms emphasize quantitative relaxation properties but remain structurally simplistic, lacking anatomical complexity and clinically relevant relative contrast. This technical note presents a practical workflow for developing high-fidelity cross-sectional MRI phantoms of the head, knee, hip, and abdomen. Representative MRI slices were manually delineated, converted into computer-aided design models, and fabricated using 3D printing. The resulting hollow structures were filled with contrast-enhanced gel-based tissue-mimicking materials. MRI acquisitions were performed to assess anatomical representation and relative tissue contrast. The proposed methodology demonstrates a low-cost and accessible approach for producing anatomically realistic MRI phantoms suitable for research, protocol development, and teaching. The workflow is adaptable and can be extended to other anatomical regions.
SN - 2211-7156
ER -