Epstein-Barr virus influences the induction of protective antibody responses in young African children…

Abstract

The RTS,S vaccine provides moderate protection against malaria in children, which may be due in part to environmental factors. Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infections are prevalent in Africa and potentially contribute to suboptimal vaccine responses. We evaluated whether latent CMV/EBV infections impact RTS,S-induced antibodies in 314 vaccinated children aged 5-29 months in West Africa. While no strong associations were observed for CMV, children seropositive for EBV had lower antigen-specific IgG and IgA, which have been linked with protective malaria immunity. These results may partly explain why malaria vaccines are suboptimal in populations where early CMV/EBV infections are prevalent.

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BibTeX

@misc{harris2026epsteinbarr,
  title = {{Epstein-Barr virus influences the induction of protective antibody responses in young African children vaccinated with the RTS,S malaria vaccine}},
  author = {A. W. Harris and A. Thomas and J.-B. Ouedraogo and H. Tinto and I. Zongo and A. Dicko and I. Sagara and D. Chandramohan and B. Greenwood and L. Kurtovic and J. Beeson},
  howpublished = {medRxiv},
  year = {2026},
  month = nov,
  doi = {10.64898/2026.11.03.26367212},
  url = {https://www.medrxiv.org/content/10.64898/2026.11.03.26367212v1},
  note = {CC BY-NC-ND},
}

RIS

TY  - UNPB
TI  - Epstein-Barr virus influences the induction of protective antibody responses in young African children vaccinated with the RTS,S malaria vaccine
AU  - A. W. Harris
AU  - A. Thomas
AU  - J.-B. Ouedraogo
AU  - H. Tinto
AU  - I. Zongo
AU  - A. Dicko
AU  - I. Sagara
AU  - D. Chandramohan
AU  - B. Greenwood
AU  - L. Kurtovic
AU  - J. Beeson
PY  - 2026
DA  - 2026/11/03
PB  - medRxiv
DO  - 10.64898/2026.11.03.26367212
UR  - https://www.medrxiv.org/content/10.64898/2026.11.03.26367212v1
AB  - The RTS,S vaccine provides moderate protection against malaria in children, which may be due in part to environmental factors. Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infections are prevalent in Africa and potentially contribute to suboptimal vaccine responses. We evaluated whether latent CMV/EBV infections impact RTS,S-induced antibodies in 314 vaccinated children aged 5-29 months in West Africa. While no strong associations were observed for CMV, children seropositive for EBV had lower antigen-specific IgG and IgA, which have been linked with protective malaria immunity. These results may partly explain why malaria vaccines are suboptimal in populations where early CMV/EBV infections are prevalent.
ER  -

Abstract

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