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Peer-reviewedCC BYInternational journal of molecular sciences

Effect of Rhodiola rosea L. Extract on Alzheimer's Disease-like Symptoms in Caenorhabditis elegans.

  • Aina Bellver-Sanchis1,2
  • Christian Griñán-Ferré1,2,3
  • Sylvain Sutour4
  • Andrey S Marchev5
5 affiliations
  1. 1Department of Pharmacology, Toxicology and Therapeutic Chemistry, University of Barcelona, Av. Joan XXIII, 27-31, 08035 Barcelona, Spain.
  2. 2Institute of Neurosciences, University of Barcelona, 08035 Barcelona, Spain.
  3. 3Centro de Investigación en Red, Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28029 Madrid, Spain.
  4. 4Neuchâtel Platform of Analytical Chemistry, University of Neuchâtel, Avenue de Bellevaux 51, 2000 Neuchâtel, Switzerland.
  5. 5Laboratory of Eukaryotic Cell Biology, Department of Biotechnology, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 139 Ruski Blvd., 4000 Plovdiv, Bulgaria.
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Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, oxidative stress, and amyloid-beta accumulation. Natural products with antioxidant and stress-response-modulating properties are increasingly being investigated as candidate neuroprotective agents. In this study, we evaluated the effects of Rhodiola rosea L. extract, salidroside, and rosavin in Caenorhabditis elegans models of AD. Phenotypic, behavioral, biochemical, and molecular assays were used to assess locomotion, egg laying, chemotaxis, reactive oxygen species (ROS), gene expression, and amyloid-like aggregation. The extract and its related compounds improved locomotor performance, partially rescued reproductive and sensory defects, reduced ROS accumulation, modulated stress-response genes including skn-1/nrf2, daf-2, and sod-1, and decreased thioflavin-S-positive aggregates. Together, these findings support the potential neuroprotective effect of R. rosea extract and its key marker compounds, suggesting the involvement of conserved antioxidant pathways.

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Cite

BibTeXRIS
BibTeX
@article{bellversanchis2026effect,
  title = {{Effect of Rhodiola rosea L. Extract on Alzheimer's Disease-like Symptoms in Caenorhabditis elegans.}},
  author = {Aina Bellver-Sanchis and Christian Griñán-Ferré and Sylvain Sutour and Andrey S Marchev},
  journal = {International journal of molecular sciences},
  year = {2026},
  month = sep,
  doi = {10.3390/ijms27198701},
  url = {https://europepmc.org/article/MED/42883945},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Effect of Rhodiola rosea L. Extract on Alzheimer's Disease-like Symptoms in Caenorhabditis elegans.
AU  - Aina Bellver-Sanchis
AU  - Christian Griñán-Ferré
AU  - Sylvain Sutour
AU  - Andrey S Marchev
PY  - 2026
DA  - 2026/09/29
JO  - International journal of molecular sciences
DO  - 10.3390/ijms27198701
UR  - https://europepmc.org/article/MED/42883945
AB  - Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, oxidative stress, and amyloid-beta accumulation. Natural products with antioxidant and stress-response-modulating properties are increasingly being investigated as candidate neuroprotective agents. In this study, we evaluated the effects of Rhodiola rosea L. extract, salidroside, and rosavin in Caenorhabditis elegans models of AD. Phenotypic, behavioral, biochemical, and molecular assays were used to assess locomotion, egg laying, chemotaxis, reactive oxygen species (ROS), gene expression, and amyloid-like aggregation. The extract and its related compounds improved locomotor performance, partially rescued reproductive and sensory defects, reduced ROS accumulation, modulated stress-response genes including skn-1/nrf2, daf-2, and sod-1, and decreased thioflavin-S-positive aggregates. Together, these findings support the potential neuroprotective effect of R. rosea extract and its key marker compounds, suggesting the involvement of conserved antioxidant pathways.
SN  - 1422-0067
ER  -