Predictors of quality of life in older adults with major psychiatric disorders: A prospective multicenter study

@article{golda2026predictors,
  title = {{Predictors of quality of life in older adults with major psychiatric disorders: A prospective multicenter study}},
  author = {Alice Golda and Marina Sánchez-Rico and Elena Ramsay-Hellawell and Mahdi Fayad and Emmanuel Leleu and Frédéric Limosin and Nicolas Hoertel and J. Adès and C. Alezrah and I. Amado and G. Amar and O. Andréi and D. Arbault and G. Archambault and G. Aurifeuille and S. Barrière and C. Béra-Potelle and Y. Blumenstock and H. Bardou and M. Bareil-Guérin and P. Barrau and C. Barrouillet and E. Baup and N. Bazin and B. Beaufils and J. Ben Ayed and M. Benoit and K. Benyacoub and T. Bichet and F. Blanadet and O. Blanc and J. Blanc-Comiti and D. Boussiron and A.M. Bouysse and A. Brochard and O. Brochart and B. Bucheron and M. Cabot and V. Camus and J.M. Chabannes and V. Charlot and T. Charpeaud and C. Clad-Mor and C. Combes and M. Comisu and B. Cordier and L. Cormier and F. Costi and J.P. Courcelles and M. Creixell and H. Cuche and Christine-Vanessa Cuervo-Lombard and A. Dammak and D. da Rin and J.B. Denis and H. Denizot and A. Deperthuis and E. Diers and S. Dirami and D. Donneau},
  journal = {Psychiatry Research},
  year = {2026},
  month = nov,
  doi = {10.1016/j.psychres.2026.117555},
  url = {https://hal.science/hal-05848301v1},
  note = {CC BY},
}

TY  - JOUR
TI  - Predictors of quality of life in older adults with major psychiatric disorders: A prospective multicenter study
AU  - Alice Golda
AU  - Marina Sánchez-Rico
AU  - Elena Ramsay-Hellawell
AU  - Mahdi Fayad
AU  - Emmanuel Leleu
AU  - Frédéric Limosin
AU  - Nicolas Hoertel
AU  - J. Adès
AU  - C. Alezrah
AU  - I. Amado
AU  - G. Amar
AU  - O. Andréi
AU  - D. Arbault
AU  - G. Archambault
AU  - G. Aurifeuille
AU  - S. Barrière
AU  - C. Béra-Potelle
AU  - Y. Blumenstock
AU  - H. Bardou
AU  - M. Bareil-Guérin
AU  - P. Barrau
AU  - C. Barrouillet
AU  - E. Baup
AU  - N. Bazin
AU  - B. Beaufils
AU  - J. Ben Ayed
AU  - M. Benoit
AU  - K. Benyacoub
AU  - T. Bichet
AU  - F. Blanadet
AU  - O. Blanc
AU  - J. Blanc-Comiti
AU  - D. Boussiron
AU  - A.M. Bouysse
AU  - A. Brochard
AU  - O. Brochart
AU  - B. Bucheron
AU  - M. Cabot
AU  - V. Camus
AU  - J.M. Chabannes
AU  - V. Charlot
AU  - T. Charpeaud
AU  - C. Clad-Mor
AU  - C. Combes
AU  - M. Comisu
AU  - B. Cordier
AU  - L. Cormier
AU  - F. Costi
AU  - J.P. Courcelles
AU  - M. Creixell
AU  - H. Cuche
AU  - Christine-Vanessa Cuervo-Lombard
AU  - A. Dammak
AU  - D. da Rin
AU  - J.B. Denis
AU  - H. Denizot
AU  - A. Deperthuis
AU  - E. Diers
AU  - S. Dirami
AU  - D. Donneau
PY  - 2026
DA  - 2026/11/02
JO  - Psychiatry Research
DO  - 10.1016/j.psychres.2026.117555
UR  - https://hal.science/hal-05848301v1
AB  - Quality of life (QoL) in older adults with major psychiatric disorders is affected by various clinical and social factors, yet longitudinal evidence on QoL determinants remains limited. This study tests a comprehensive model of predictors of QoL using structural equation modelling (SEM). We analysed data from the Cohort of individuals with Schizophrenia Aged 55 years or more (CSA) study, a multicenter cohort of older adults diagnosed with schizophrenia, bipolar disorder, or major depressive disorder, recruited from 63 French psychiatric centers. QoL was assessed using the Quality-of-Life Scale (QLS) at baseline and follow-up (median = 3.0 years, SD = 1.44). We examined the simultaneous effects on QLS at follow-up of six predictor groups assessed at baseline, including (1) severity of general psychopathology, (2) severity of depressive symptoms, (3) severity of cognitive impairment, (4) psychotropic medications, (5) general medical conditions, and (6) sociodemographic characteristics. Six predictors showed significant independent longitudinal associations with QoL. Lower QoL was associated with greater depressive symptoms (β=-0.225), greater cognitive impairment (β=-0.117), antipsychotic polypharmacy (β=-0.538) and longer follow-up (β=-0.330) (all p-values<0.05). In contrast, higher baseline QoL (β=0.401) and greater levels of general psychopathology (β=0.291) were positively associated with follow-up QoL. Depression, cognitive impairment and antipsychotic polypharmacy emerged as markers of poorer QoL, independently of baseline QoL and diagnosis, although the association with depression was not robust in sensitivity analyses. The unexpected positive association with psychopathology is compatible with statistical suppression, measurement overlap, survival bias and limited illness awareness rather than a true benefit of symptoms.
SN  - 0165-1781
SN  - 1872-7123
ER  -