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Peer-reviewedLicence not statedNature genetics

Distinguishing different psychiatric disorders using DDx-PRS

  • Wouter J. Peyrot1,2,3
  • Georgia Panagiotaropoulou4
  • Loes M. Olde Loohuis5,6,7
  • Mark J. Adams8
  • Ole A. Andreassen9,10,11
  • Swapnil Awasthi4
  • Andreas J. Forstner12,13
  • Tian Ge14,15
  • Andrew M. McIntosh8
  • Brittany L. Mitchell16
  • Niamh Mullins17,18,19
  • Kevin S. O’Connell9,20
43 more authors
  • Brenda W.J.H. Penninx1,3
  • Danielle Posthuma2
  • Stephan Ripke4,21,22
  • Douglas M. Ruderfer23,24,25
  • Emil Uffelmann2
  • Bjarni J. Vilhjalmsson26,27,28
  • Zhihong Zhu26
  • Nick Bass
  • Nick Bass29
  • Aiden Corvin30
  • Ina Giegling31
  • Annette M. Hartmann31
  • Kenneth S. Kendler32
  • George K. Kirov33
  • Sophie E. Legge33
  • Andrew McQuillin29
  • Michael M.C. O’Donovan33
  • Anthony F. O’Neill34
  • Michael J. Owen33
  • Antonio F. Pardiñas33
  • Brien P. Riley35
  • Dan Rujescu31
  • James T. Walters33
  • Daniel R. Weinberger36
  • Nick Bass
  • Nick Bass29
  • Susanne A. Bengesser37
  • Joanna M. Biernacka38,39
  • Nina Dalkner37
  • Arianna Di Florio33
  • Frederike T. Fellendorf37
  • Mark A. Frye40
  • Melanie Lenger37
  • Susan L. McElroy
  • Andrew McQuillin29
  • Eva Z. Reininghaus37
  • Mark J. Adams
  • Mark J. Adams8
  • Gerome Breen
  • Cathryn M. Lewis
  • Andrew M. McIntosh8
  • Jordan W. Smoller14,15
  • Alkes L. Price
40 affiliations
  1. 1Department of Psychiatry, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands
  2. 2Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Netherlands
  3. 3Amsterdam Public Health, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands
  4. 4Dept. of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin 10117, Germany
  5. 5Center for Neurobehavioral Genetics, University of California Los Angeles, Los Angeles, CA, USA
  6. 6Department of Genetics and Genomics, University of California Los Angeles, Los Angeles, CA, USA
  7. 7Department of Computational Medicine, University of California Los Angeles, Los Angeles, CA, USA
  8. 8Institute of Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK
  9. 9Division of Mental Health and Addiction, Oslo University Hospital, Oslo, NO
  10. 10Centre for Precision Psychiatry, University of Oslo, Oslo, NO
  11. 11KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Oslo, NO
  12. 12Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany
  13. 13Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany
  14. 14Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA
  15. 15Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
  16. 16Mental Health and Neuroscience, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia
  17. 17Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, US
  18. 18Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, US
  19. 19Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, US
  20. 20NORMENT, University of Oslo, Oslo, NO
  21. 21Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge MA 02142, USA
  22. 22German Center for Mental Health (DZPG), site Berlin-Potsdam
  23. 23Center for Digital Genomic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, US
  24. 24Departments of Biomedical Informatics and Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, US
  25. 25Division of Genetic Medicine, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, US
  26. 26National Centre for Register-based Research, Aarhus University, Aarhus, Denmark
  27. 27Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark
  28. 28Novo Nordisk Foundation Center for Genomics Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA
  29. 29Division of Psychiatry, University College London, London, UK
  30. 30Department of Psychiatry, Trinity College Dublin, Dublin, Ireland
  31. 31Department of Psychiatry and Psychotherapy, Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Austria
  32. 32Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond VA, USA
  33. 33Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Clinical Neurosciences, Cardiff University School Of Medicine, Cardiff CF24 4HQ, UK
  34. 34Centre For Public Health, Institute Of Clinical Sciences, Queens University Belfast, Belfast, NI
  35. 35Virginia Institute for Psychiatric and Behavioral Genetics, Departments of Psychiatry and Cellular, Molecular & Genetic Medicine, Virginia Commonwealth University, Richmond VA, USA
  36. 36Lieber Institute for Brain Development, Departments of Psychiatry, Neurology, Neuroscience and Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Md. 21205 USA
  37. 37Clinical Division of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Austria
  38. 38Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA
  39. 39Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA
  40. 40Department of Psychiatry and Psychology, Mayo Clinic, Rochester MN, USA 55905
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Cite

BibTeXRIS
BibTeX
@article{peyrot2026distinguishing,
  title = {{Distinguishing different psychiatric disorders using DDx-PRS}},
  author = {Wouter J. Peyrot and Georgia Panagiotaropoulou and Loes M. Olde Loohuis and Mark J. Adams and Ole A. Andreassen and Swapnil Awasthi and Andreas J. Forstner and Tian Ge and Andrew M. McIntosh and Brittany L. Mitchell and Niamh Mullins and Kevin S. O’Connell and Brenda W.J.H. Penninx and Danielle Posthuma and Stephan Ripke and Douglas M. Ruderfer and Emil Uffelmann and Bjarni J. Vilhjalmsson and Zhihong Zhu and Nick Bass and Nick Bass and Aiden Corvin and Ina Giegling and Annette M. Hartmann and Kenneth S. Kendler and George K. Kirov and Sophie E. Legge and Andrew McQuillin and Michael M.C. O’Donovan and Anthony F. O’Neill and Michael J. Owen and Antonio F. Pardiñas and Brien P. Riley and Dan Rujescu and James T. Walters and Daniel R. Weinberger and Nick Bass and Nick Bass and Susanne A. Bengesser and Joanna M. Biernacka and Nina Dalkner and Arianna Di Florio and Frederike T. Fellendorf and Mark A. Frye and Melanie Lenger and Susan L. McElroy and Andrew McQuillin and Eva Z. Reininghaus and Mark J. Adams and Mark J. Adams and Gerome Breen and Cathryn M. Lewis and Andrew M. McIntosh and Jordan W. Smoller and Alkes L. Price},
  journal = {Nature genetics},
  year = {2026},
  month = aug,
  doi = {10.1038/s41588-026-02684-x},
  url = {https://doi.org/10.1038/s41588-026-02684-x},
}
RIS
TY  - JOUR
TI  - Distinguishing different psychiatric disorders using DDx-PRS
AU  - Wouter J. Peyrot
AU  - Georgia Panagiotaropoulou
AU  - Loes M. Olde Loohuis
AU  - Mark J. Adams
AU  - Ole A. Andreassen
AU  - Swapnil Awasthi
AU  - Andreas J. Forstner
AU  - Tian Ge
AU  - Andrew M. McIntosh
AU  - Brittany L. Mitchell
AU  - Niamh Mullins
AU  - Kevin S. O’Connell
AU  - Brenda W.J.H. Penninx
AU  - Danielle Posthuma
AU  - Stephan Ripke
AU  - Douglas M. Ruderfer
AU  - Emil Uffelmann
AU  - Bjarni J. Vilhjalmsson
AU  - Zhihong Zhu
AU  - Nick Bass
AU  - Nick Bass
AU  - Aiden Corvin
AU  - Ina Giegling
AU  - Annette M. Hartmann
AU  - Kenneth S. Kendler
AU  - George K. Kirov
AU  - Sophie E. Legge
AU  - Andrew McQuillin
AU  - Michael M.C. O’Donovan
AU  - Anthony F. O’Neill
AU  - Michael J. Owen
AU  - Antonio F. Pardiñas
AU  - Brien P. Riley
AU  - Dan Rujescu
AU  - James T. Walters
AU  - Daniel R. Weinberger
AU  - Nick Bass
AU  - Nick Bass
AU  - Susanne A. Bengesser
AU  - Joanna M. Biernacka
AU  - Nina Dalkner
AU  - Arianna Di Florio
AU  - Frederike T. Fellendorf
AU  - Mark A. Frye
AU  - Melanie Lenger
AU  - Susan L. McElroy
AU  - Andrew McQuillin
AU  - Eva Z. Reininghaus
AU  - Mark J. Adams
AU  - Mark J. Adams
AU  - Gerome Breen
AU  - Cathryn M. Lewis
AU  - Andrew M. McIntosh
AU  - Jordan W. Smoller
AU  - Alkes L. Price
PY  - 2026
DA  - 2026/08/20
JO  - Nature genetics
DO  - 10.1038/s41588-026-02684-x
UR  - https://doi.org/10.1038/s41588-026-02684-x
SN  - 1061-4036
SN  - 1546-1718
ER  -