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Peer-reviewedCC BYPLOS Medicine

Seeing the invisible: Reorienting cardiovascular risk prediction across the disease trajectory

  • Xun Tang1,2,3
  • Pei Gao1,2,3
  1. 1Institute of Advanced Clinical Medicine, Peking University, Beijing, China.
  2. 2Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
  3. 3Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China.
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Abstract

Current risk equations miss many cardiovascular events in people classified as low risk. Prediction is simultaneously advancing on two axes: broadening predictors toward molecular omics, and expanding outcomes toward earlier subclinical atherosclerosis and later heart failure.

In this Perspective, Xun Tang and Pei Gao discuss how cardiovascular risk prediction is simultaneously advancing on two axes: broadening predictors toward molecular omics, and expanding outcomes toward earlier subclinical atherosclerosis and later heart failure.

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Cite

BibTeXRIS
BibTeX
@article{tang2026seeing,
  title = {{Seeing the invisible: Reorienting cardiovascular risk prediction across the disease trajectory}},
  author = {Xun Tang and Pei Gao},
  journal = {PLOS Medicine},
  year = {2026},
  month = oct,
  doi = {10.1371/journal.pmed.1005263},
  url = {https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1005263},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Seeing the invisible: Reorienting cardiovascular risk prediction across the disease trajectory
AU  - Xun Tang
AU  - Pei Gao
PY  - 2026
DA  - 2026/10/21
JO  - PLOS Medicine
DO  - 10.1371/journal.pmed.1005263
UR  - https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1005263
AB  - Current risk equations miss many cardiovascular events in people classified as low risk. Prediction is simultaneously advancing on two axes: broadening predictors toward molecular omics, and expanding outcomes toward earlier subclinical atherosclerosis and later heart failure.  In this Perspective, Xun Tang and Pei Gao discuss how cardiovascular risk prediction is simultaneously advancing on two axes: broadening predictors toward molecular omics, and expanding outcomes toward earlier subclinical atherosclerosis and later heart failure.
SN  - 1549-1676
SN  - 1549-1277
ER  -