Quantitative Characterization of Pharmaceutical Powder Surface Interactions Using Inverse Gas Chromatography-Derived Surface Energy Profiles
- 1Chugai Pharmaceutical Co., Ltd.
- 2Gifu Pharmaceutical University
Abstract
Quantitative characterization of surface and interfacial properties is important for understanding the behavior of pharmaceutical powders, but conventional approaches to powder wettability and surface free energy can be influenced by measurement procedures and sample-specific factors. Inverse gas chromatography (IGC) provides a sensitive approach for characterizing powder surface energetics as a function of fractional surface coverage; however, the reproducibility and interpretation of IGC-derived surface energy profiles require careful evaluation. In this study, the reproducibility of IGC-derived surface energy profiles was examined using pharmaceutical excipients, and the resulting energetic characteristics were compared with wettability measurements obtained using sessile drop and Washburn methods. Surface-energy profiles were further used to calculate thermodynamic work-of-adhesion profiles for powder–water interactions and for drug–excipient systems. Distinct differences in surface-energy profiles were observed among pharmaceutical excipients, including materials with identical nominal chemical compositions but different grades. Drug–excipient work-of-adhesion profiles further demonstrated coverage-dependent differences in calculated interfacial interactions among pharmaceutical materials. The results demonstrate that IGC-derived surface-energy profiles can provide reproducible characterization of pharmaceutical powder surfaces and can be extended to quantitative evaluation of solid–liquid and solid–solid interfacial interactions. These findings support the use of surface-energy profiles as a quantitative framework for characterization of pharmaceutical powders and for comparison of potential interfacial interactions among formulation components.
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BibTeX
@misc{yoshioka2026quantitative,
title = {{Quantitative Characterization of Pharmaceutical Powder Surface Interactions Using Inverse Gas Chromatography-Derived Surface Energy Profiles}},
author = {Ken Yoshioka and Kohei Tahara},
howpublished = {ChemRxiv},
year = {2026},
month = oct,
doi = {10.26434/chemrxiv.15010186/v1},
url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010186/v1},
note = {CC BY},
}
RIS
TY - UNPB
TI - Quantitative Characterization of Pharmaceutical Powder Surface Interactions Using Inverse Gas Chromatography-Derived Surface Energy Profiles
AU - Ken Yoshioka
AU - Kohei Tahara
PY - 2026
DA - 2026/10/09
PB - ChemRxiv
DO - 10.26434/chemrxiv.15010186/v1
UR - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010186/v1
AB - Quantitative characterization of surface and interfacial properties is important for understanding the behavior of pharmaceutical powders, but conventional approaches to powder wettability and surface free energy can be influenced by measurement procedures and sample-specific factors. Inverse gas chromatography (IGC) provides a sensitive approach for characterizing powder surface energetics as a function of fractional surface coverage; however, the reproducibility and interpretation of IGC-derived surface energy profiles require careful evaluation. In this study, the reproducibility of IGC-derived surface energy profiles was examined using pharmaceutical excipients, and the resulting energetic characteristics were compared with wettability measurements obtained using sessile drop and Washburn methods. Surface-energy profiles were further used to calculate thermodynamic work-of-adhesion profiles for powder–water interactions and for drug–excipient systems. Distinct differences in surface-energy profiles were observed among pharmaceutical excipients, including materials with identical nominal chemical compositions but different grades. Drug–excipient work-of-adhesion profiles further demonstrated coverage-dependent differences in calculated interfacial interactions among pharmaceutical materials. The results demonstrate that IGC-derived surface-energy profiles can provide reproducible characterization of pharmaceutical powder surfaces and can be extended to quantitative evaluation of solid–liquid and solid–solid interfacial interactions. These findings support the use of surface-energy profiles as a quantitative framework for characterization of pharmaceutical powders and for comparison of potential interfacial interactions among formulation components.
ER -