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PreprintCC BY-SA 4.0Zenodo

A Corrected Hyperinsulinemic Risk Metric: The Glyco-Insulinemic Risk Ratio Prime (HRR )

  • SİNAN İBAGÜNER1
  1. 1Independent
Open at sourcePDFDOICite

Abstract

Conventional dietary risk metrics such as the Glycemic Index (GI) and Insulinemic Index (II) fail to distinguish between pathological glucose-driven hyperinsulinemia and physiological amino-acid-induced insulin signaling. In particular, ratio-based constructions of insulin-to-glucose responses lead to mathematical singularities and empirical misclassification of metabolically protective foods. We introduce a corrected functional, the Hyperinsulinemic Risk Ratio Prime (HRR), which quantifies time-weighted glyco-insulinemic overlap rather than insulin magnitude alone. The proposed metric is mathematically well-posed, physiologically grounded, and resolves known paradoxes such as the high insulinemic index of fish.

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Cite

BibTeXRIS
BibTeX
@misc{ibaguner2026corrected,
  title = {{A Corrected Hyperinsulinemic Risk Metric: The Glyco-Insulinemic Risk Ratio Prime (HRR )}},
  author = {SİNAN İBAGÜNER},
  howpublished = {Zenodo},
  year = {2026},
  month = oct,
  doi = {10.13140/rg.2.2.33120.24326},
  url = {https://zenodo.org/records/23619012},
  note = {CC BY-SA 4.0},
}
RIS
TY  - UNPB
TI  - A Corrected Hyperinsulinemic Risk Metric: The Glyco-Insulinemic Risk Ratio Prime (HRR )
AU  - SİNAN İBAGÜNER
PY  - 2026
DA  - 2026/10/24
PB  - Zenodo
DO  - 10.13140/rg.2.2.33120.24326
UR  - https://zenodo.org/records/23619012
AB  - Conventional dietary risk metrics such as the Glycemic Index (GI) and Insulinemic Index (II) fail to distinguish between pathological glucose-driven hyperinsulinemia and physiological amino-acid-induced insulin signaling. In particular, ratio-based constructions of insulin-to-glucose responses lead to mathematical singularities and empirical misclassification of metabolically protective foods. We introduce a corrected functional, the Hyperinsulinemic Risk Ratio Prime (HRR), which quantifies time-weighted glyco-insulinemic overlap rather than insulin magnitude alone. The proposed metric is mathematically well-posed, physiologically grounded, and resolves known paradoxes such as the high insulinemic index of fish.
ER  -