Phytochemical Profiles of Artemisia albida Willd.: Potential for PTP1B, α-Glucosidase, BNA, DPPH and Molecular Docking Analysis
7 affiliations
- 1University of Chinese Academy of Sciences, Beijing 100049, China
- 2Natural Product Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
- 3Research Center for Medicinal Plants, Farabi University, Almaty 050040, Kazakhstan
- 4Research Institute for Natural Products & Technology, Almaty 050046, Kazakhstan
- 5Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China
- 6Central Asian of Drug Discovery and Development, Xinjiang Technical Institutes of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China
- 7China-Serbia “Belt and Road” Joint Laboratory for Natural Products and Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
Abstract
Traditional herbal medicine has been an important source of therapeutic agents to treat various diseases since long ago and the genus Artemisia is drawing a lot of attention owing to its diversity of biologically active secondary metabolites. In the present study, our team focused on Artemisia albida Willd., which was collected in the Almaty region of Kazakhstan. Using various chromatographic techniques, 15 compounds were obtained. Their structures were elucidated by HRESIMS, NMR, and ECD, revealing a new-skeleton sesquiterpenoid, Albiterpene A (1), together with one known sesquiterpene, one lignan, one fatty acid ester, and 11 phenolic compounds. The absolute configuration of Albiterpene A was determined by the TDDFT ECD calculation. Meanwhile, the inhibitory and radical-scavenging activities of the isolated compounds were evaluated using α-glucosidase, PTP1B, BNA and DPPH assays. Among all tested compounds, arteanoflavone exhibited the most potent α-glucosidase (IC50 = 3.2 ± 0.07 μM) and PTP1B (IC50 = 6.8 ± 0.14 μM) inhibition and strong DPPH radical-scavenging activity (IC50 = 1.5 ± 0.03 μM), outperforming the positive controls DNJ and Trolox. Molecular docking was employed to elucidate the possible binding modes of arteanoflavone, chlorogenic acid, and caffeic acid ethyl ester against PTP1B (1NNY) and human α-glucosidase (2QMJ). The docking scores suggested a consistent binding affinity ranking across both targets: chlorogenic acid > arteanoflavone > caffeic acid ethyl ester.
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BibTeX
@article{jenis2026phytochemical,
title = {{Phytochemical Profiles of Artemisia albida Willd.: Potential for PTP1B, α-Glucosidase, BNA, DPPH and Molecular Docking Analysis}},
author = {Janar Jenis and Ayaulym Minkayeva and Chunping Tang and Changqiang Ke and Aizhamal Baiseitova and Xiaofei Shang and Haji Akber Aisa and Yang Ye},
journal = {Molecules},
year = {2026},
month = nov,
doi = {10.3390/molecules31213975},
url = {https://www.mdpi.com/1420-3049/31/21/3975},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Phytochemical Profiles of Artemisia albida Willd.: Potential for PTP1B, α-Glucosidase, BNA, DPPH and Molecular Docking Analysis
AU - Janar Jenis
AU - Ayaulym Minkayeva
AU - Chunping Tang
AU - Changqiang Ke
AU - Aizhamal Baiseitova
AU - Xiaofei Shang
AU - Haji Akber Aisa
AU - Yang Ye
PY - 2026
DA - 2026/11/04
JO - Molecules
DO - 10.3390/molecules31213975
UR - https://www.mdpi.com/1420-3049/31/21/3975
AB - Traditional herbal medicine has been an important source of therapeutic agents to treat various diseases since long ago and the genus Artemisia is drawing a lot of attention owing to its diversity of biologically active secondary metabolites. In the present study, our team focused on Artemisia albida Willd., which was collected in the Almaty region of Kazakhstan. Using various chromatographic techniques, 15 compounds were obtained. Their structures were elucidated by HRESIMS, NMR, and ECD, revealing a new-skeleton sesquiterpenoid, Albiterpene A (1), together with one known sesquiterpene, one lignan, one fatty acid ester, and 11 phenolic compounds. The absolute configuration of Albiterpene A was determined by the TDDFT ECD calculation. Meanwhile, the inhibitory and radical-scavenging activities of the isolated compounds were evaluated using α-glucosidase, PTP1B, BNA and DPPH assays. Among all tested compounds, arteanoflavone exhibited the most potent α-glucosidase (IC50 = 3.2 ± 0.07 μM) and PTP1B (IC50 = 6.8 ± 0.14 μM) inhibition and strong DPPH radical-scavenging activity (IC50 = 1.5 ± 0.03 μM), outperforming the positive controls DNJ and Trolox. Molecular docking was employed to elucidate the possible binding modes of arteanoflavone, chlorogenic acid, and caffeic acid ethyl ester against PTP1B (1NNY) and human α-glucosidase (2QMJ). The docking scores suggested a consistent binding affinity ranking across both targets: chlorogenic acid > arteanoflavone > caffeic acid ethyl ester.
SN - 1420-3049
ER -