KDM5A overexpression modulates key myogenic differentiation factors and sarcomere gene expression.
4 affiliations
- 1Translational Neurosciences and Peripheral Neuropathy Group, UAntwerp, Antwerp, VLG, BE.
- 2Laboratory of Neuromuscular Pathology, Institute Born-Bunge, UAntwerp, Antwerp, VLG, BE.
- 3Peripheral Neuropathy Research Group, Department of Biomedical Sciences, UAntwerp, Antwerp, VLG, BE.
- 4Department of Neurology, Neuromuscular Reference Centre, Antwerp UH, Antwerp, VLG, BE.
Abstract
Myogenic differentiation is a complex and tightly regulated process involving multiple transcriptional regulators. KDM5A (lysine demethylase 5A) is a histone demethylase that regulates gene transcription and has been implicated in skeletal muscle differentiation. In Inclusion Body Myositis, we previously associated dysregulated myogenic differentiation with KDM5A overactivity. Immortalised human myoblasts overexpressing KDM5A showed an altered transcriptional landscape, with differential expression of key myogenic differentiation factors and significantly increased expression of sarcomeric genes. Although no morphological differences were observed, KDM5A-overexpressing myotubes showed a higher proportion of myogenin-positive nuclei during late-stage differentiation, suggesting that KDM5A modulates myogenic differentiation dynamics.
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BibTeX
@article{vries2026kdm5a,
title = {{KDM5A overexpression modulates key myogenic differentiation factors and sarcomere gene expression.}},
author = {Geert de Vries and Alice Monticelli and Vicky De Winter and Danique Beijer and Willem De Ridder and Jonathan Baets},
journal = {MicroPublication biology},
year = {2026},
month = oct,
doi = {10.17912/micropub.biology.002136},
url = {https://europepmc.org/article/MED/42923842},
note = {CC BY},
}
RIS
TY - JOUR
TI - KDM5A overexpression modulates key myogenic differentiation factors and sarcomere gene expression.
AU - Geert de Vries
AU - Alice Monticelli
AU - Vicky De Winter
AU - Danique Beijer
AU - Willem De Ridder
AU - Jonathan Baets
PY - 2026
DA - 2026/10/07
JO - MicroPublication biology
DO - 10.17912/micropub.biology.002136
UR - https://europepmc.org/article/MED/42923842
AB - Myogenic differentiation is a complex and tightly regulated process involving multiple transcriptional regulators. KDM5A (lysine demethylase 5A) is a histone demethylase that regulates gene transcription and has been implicated in skeletal muscle differentiation. In Inclusion Body Myositis, we previously associated dysregulated myogenic differentiation with KDM5A overactivity. Immortalised human myoblasts overexpressing KDM5A showed an altered transcriptional landscape, with differential expression of key myogenic differentiation factors and significantly increased expression of sarcomeric genes. Although no morphological differences were observed, KDM5A-overexpressing myotubes showed a higher proportion of myogenin-positive nuclei during late-stage differentiation, suggesting that KDM5A modulates myogenic differentiation dynamics.
SN - 2578-9430
ER -