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Peer-reviewedCC BY 4.0Frontiers in Neurology

Association between psychosocial consequences of visual dysfunction and depressive symptom burden in multiple sclerosis and neuromyelitis optica spectrum disorder

  • Guoxun Zhang1
  • Han Wang1
  • Xiaojia Sun2
  • Yu Liu2
  • Chunyang Li1
  • Xiao Yang3
  • Jia Guo4
  • Huaxing Meng5
  • Xuelan Ye6
  • Di Zhong7
  • Hongmei Wang1
  • Yanru He2
6 more authors
  • Dongjie Sun2
  • Jinting Zhu2
  • Lili Ge2
  • Qiwu Zhou2
  • Kin Chiu8
  • Runze Zhao2
8 affiliations
  1. 1Department of Neurology, Xianyang Hospital of Yan'an University
  2. 2Department of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, Fourth Military Medical University
  3. 3Department of Neurology, General Hospital of Ningxia Medical University
  4. 4Department of Neurology, The Second Hospital of Lanzhou University
  5. 5Department of Neurology, The First Affiliated Hospital of Shanxi Medical University
  6. 6Department of Neurology, Qinghai University Affiliated Hospital
  7. 7Department of Neurology, The First Affiliated Hospital of Harbin Medical University
  8. 8Department of Psychology, The University of Hong Kong
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Abstract

Visual dysfunction and depressive symptoms are common and often disabling manifestations of multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). In this multicenter cross-sectional study, 458 adults with MS ( n = 370) or NMOSD ( n = 88) were recruited from six tertiary hospitals in China. Vision-related quality of life (VRQoL) was assessed using the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25), depressive symptoms using the Hospital Anxiety and Depression Scale depression subscale (HADS-D), and objective visual impairment using World Health Organization blindness criteria. Lower NEI VFQ-25 scores were associated with HADS-D screen positivity after adjustment for measured covariates (OR 2.33 per 10-point decrease, 95% CI 1.81–3.00; p < 0.001), whereas WHO-defined blindness was not significantly associated with HADS-D screen positivity in the fully adjusted model. In domain-specific analyses, associations for Core Visual Function were attenuated after mutual adjustment, whereas Psychosocial scores remained associated with HADS-D screen positivity. These cross-sectional findings suggest that vision-related patient-reported outcomes capture aspects of functional and psychosocial disease burden that are not fully reflected by a binary classification of visual impairment.

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Cite

BibTeXRIS
BibTeX
@article{zhang2026association,
  title = {{Association between psychosocial consequences of visual dysfunction and depressive symptom burden in multiple sclerosis and neuromyelitis optica spectrum disorder}},
  author = {Guoxun Zhang and Han Wang and Xiaojia Sun and Yu Liu and Chunyang Li and Xiao Yang and Jia Guo and Huaxing Meng and Xuelan Ye and Di Zhong and Hongmei Wang and Yanru He and Dongjie Sun and Jinting Zhu and Lili Ge and Qiwu Zhou and Kin Chiu and Runze Zhao},
  journal = {Frontiers in Neurology},
  year = {2026},
  month = oct,
  doi = {10.3389/fneur.2026.1975600},
  url = {https://www.frontiersin.org/articles/10.3389/fneur.2026.1975600/full},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Association between psychosocial consequences of visual dysfunction and depressive symptom burden in multiple sclerosis and neuromyelitis optica spectrum disorder
AU  - Guoxun Zhang
AU  - Han Wang
AU  - Xiaojia Sun
AU  - Yu Liu
AU  - Chunyang Li
AU  - Xiao Yang
AU  - Jia Guo
AU  - Huaxing Meng
AU  - Xuelan Ye
AU  - Di Zhong
AU  - Hongmei Wang
AU  - Yanru He
AU  - Dongjie Sun
AU  - Jinting Zhu
AU  - Lili Ge
AU  - Qiwu Zhou
AU  - Kin Chiu
AU  - Runze Zhao
PY  - 2026
DA  - 2026/10/20
JO  - Frontiers in Neurology
DO  - 10.3389/fneur.2026.1975600
UR  - https://www.frontiersin.org/articles/10.3389/fneur.2026.1975600/full
AB  - Visual dysfunction and depressive symptoms are common and often disabling manifestations of multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). In this multicenter cross-sectional study, 458 adults with MS ( n = 370) or NMOSD ( n = 88) were recruited from six tertiary hospitals in China. Vision-related quality of life (VRQoL) was assessed using the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25), depressive symptoms using the Hospital Anxiety and Depression Scale depression subscale (HADS-D), and objective visual impairment using World Health Organization blindness criteria. Lower NEI VFQ-25 scores were associated with HADS-D screen positivity after adjustment for measured covariates (OR 2.33 per 10-point decrease, 95% CI 1.81–3.00; p < 0.001), whereas WHO-defined blindness was not significantly associated with HADS-D screen positivity in the fully adjusted model. In domain-specific analyses, associations for Core Visual Function were attenuated after mutual adjustment, whereas Psychosocial scores remained associated with HADS-D screen positivity. These cross-sectional findings suggest that vision-related patient-reported outcomes capture aspects of functional and psychosocial disease burden that are not fully reflected by a binary classification of visual impairment.
SN  - 1664-2295
ER  -