A Comprehensive Review on Ferula oopoda (Boiss. and Buhse) Boiss.: Bioactive Compounds and Pharmacological Significance.
5 affiliations
- 1Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung, Taiwan.
- 2Department of Aquatic Resources Management, Faculty of Fisheries and Marine Sciences, Brawijaya University, Jl. Veteran Malang, Indonesia.
- 3Institute of Chemical Sciences, Gomal University, Khyber Pakhtunkhwa, Pakistan.
- 4Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, Kazakhstan.
- 5School of Chemical Engineering, Kazakh-British Technical University, Almaty, Kazakhstan.
Abstract
Ferula oopoda (Boiss. and Buhse) Boiss. is an ethnomedicinally important species widely used in Central and South Asia for the treatment of gastrointestinal, respiratory, neurological, and parasitic disorders. Despite its extensive traditional applications, comprehensive scientific evaluation of its pharmacological potential remains limited. This review systematically analyzes, for the first time, the available literature on the botany, phytochemical composition, ethnomedicinal uses, and pharmacological activities of F. oopoda, while highlighting current research gaps and future perspectives for drug discovery. To date, thirty-three secondary metabolites have been isolated from F. oopoda, including sesquiterpene lactones (STLs), sesquiterpenoids, monoterpene-phenyl esters, and phenolic acid glucosides. In addition, gas chromatography mass spectrometry (GC-MS) and liquid chromatography mass spectrometry (LC-MS) analyses detected several low-molecular-weight constituents in essential oils and organic extracts. Both crude extracts and isolated compounds have displayed a broad spectrum of biological activities, including antibacterial, anti-plasmodial, antioxidant, anti-inflammatory, antimutagenic, and antiulcer effects. However, detailed mechanistic studies, pharmacokinetic investigations, and in vivo validations remain limited. Future research integrating structure-activity relationship studies and molecular target identification with omics-based approaches (e.g., metabolomics), in silico techniques such as molecular docking, and nano-drug delivery systems will be essential to advance its development into evidence-based therapeutic agents.
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BibTeX
@article{ali2026comprehensive,
title = {{A Comprehensive Review on Ferula oopoda (Boiss. and Buhse) Boiss.: Bioactive Compounds and Pharmacological Significance.}},
author = {Muhammad Ali and Setya Widi Ayuning Permanasari and Shah Iram Niaz and Aizhamal Baiseitova and Abdul Bari Shah and Yuan Bin Cheng},
journal = {Chemistry \& biodiversity},
year = {2026},
month = oct,
doi = {10.1002/cbdv.71851},
url = {https://europepmc.org/article/MED/42902935},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - A Comprehensive Review on Ferula oopoda (Boiss. and Buhse) Boiss.: Bioactive Compounds and Pharmacological Significance.
AU - Muhammad Ali
AU - Setya Widi Ayuning Permanasari
AU - Shah Iram Niaz
AU - Aizhamal Baiseitova
AU - Abdul Bari Shah
AU - Yuan Bin Cheng
PY - 2026
DA - 2026/10/01
JO - Chemistry & biodiversity
DO - 10.1002/cbdv.71851
UR - https://europepmc.org/article/MED/42902935
AB - Ferula oopoda (Boiss. and Buhse) Boiss. is an ethnomedicinally important species widely used in Central and South Asia for the treatment of gastrointestinal, respiratory, neurological, and parasitic disorders. Despite its extensive traditional applications, comprehensive scientific evaluation of its pharmacological potential remains limited. This review systematically analyzes, for the first time, the available literature on the botany, phytochemical composition, ethnomedicinal uses, and pharmacological activities of F. oopoda, while highlighting current research gaps and future perspectives for drug discovery. To date, thirty-three secondary metabolites have been isolated from F. oopoda, including sesquiterpene lactones (STLs), sesquiterpenoids, monoterpene-phenyl esters, and phenolic acid glucosides. In addition, gas chromatography mass spectrometry (GC-MS) and liquid chromatography mass spectrometry (LC-MS) analyses detected several low-molecular-weight constituents in essential oils and organic extracts. Both crude extracts and isolated compounds have displayed a broad spectrum of biological activities, including antibacterial, anti-plasmodial, antioxidant, anti-inflammatory, antimutagenic, and antiulcer effects. However, detailed mechanistic studies, pharmacokinetic investigations, and in vivo validations remain limited. Future research integrating structure-activity relationship studies and molecular target identification with omics-based approaches (e.g., metabolomics), in silico techniques such as molecular docking, and nano-drug delivery systems will be essential to advance its development into evidence-based therapeutic agents.
SN - 1612-1872
SN - 1612-1880
ER -