Lack of Association Between CAT rs1001179 and SOD2 rs4880 Variants and Risk for Multiple Sclerosis
6 affiliations
- 1Institute of Molecular Pathology Biomarkers, University of Extremadura, Av/de la Universidad S/N, 10071 Cáceres, Spain
- 2CIBERNED (Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas), Instituto de Salud Carlos III, 28029 Madrid, Spain
- 3Service of Neurology, Hospital Universitario Doce de Octubre, 28041 Madrid, Spain
- 4Section of Neurology, Hospital La Mancha-Centro, Ciudad Real, 13600 Alcázar de San Juan, Spain
- 5Section of Neurology, Hospital Universitario del Sureste, Arganda del Rey, 28500 Madrid, Spain
- 6Department of Medicine-Neurology, Hospital “Príncipe de Asturias”, Universidad de Alcalá, Alcalá de Henares, 28801 Madrid, Spain
Abstract
Objectives: Several lines of evidence point to a potential involvement of oxidative stress in the pathophysiology of multiple sclerosis (MS). Superoxide dismutase isoenzymes 1 and 2 (SOD1 and SOD2) and catalase (CAT) are key components of the enzymatic antioxidant defense system. Consequently, genetic variation in the genes encoding these enzymes may influence susceptibility to MS. However, previous studies examining the relationship between SOD1, SOD2, and CAT variants and MS susceptibility have yielded inconsistent findings. The present study aimed to investigate whether two common single-nucleotide variants (SNVs) in CAT and SOD2 are associated with MS risk in a Caucasian Spanish population. Methods: We investigated the CAT rs1001179 and SOD2 rs4880 variants in 300 patients with MS and 400 healthy controls using allele-specific TaqMan quantitative PCR assays. We further examined whether these variants were related to relevant clinical characteristics, including age at disease onset, disease severity, and clinical course/subtype. Results: Neither the genotype nor allele distributions of CAT rs1001179 and SOD2 rs4880 differed significantly between patients with MS and healthy controls. Furthermore, no significant relationships were observed between either variant and sex, age at disease onset, disease severity, or clinical MS subtype. Conclusions: The present study did not detect significant associations between the CAT rs1001179 or SOD2 rs4880 variants and MS susceptibility in the Caucasian Spanish population. Similarly, no significant associations were detected between these variants and the clinical characteristics evaluated. However, smaller genetic effects cannot be excluded.
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BibTeX
@article{garciamartin2026lack,
title = {{Lack of Association Between CAT rs1001179 and SOD2 rs4880 Variants and Risk for Multiple Sclerosis}},
author = {Elena García-Martín and Javier Gómez-Tabales and José A. G. Agúndez and Julián Benito-León and Jorge Millán-Pascual and María Díaz-Sánchez and Patricia Calleja and Laura Turpín-Fenoll and Hortensia Alonso-Navarro and Esteban García-Albea and Félix Javier Jiménez-Jiménez},
journal = {Biomolecules},
year = {2026},
month = oct,
doi = {10.3390/biom16101449},
url = {https://www.mdpi.com/2218-273X/16/10/1449},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Lack of Association Between CAT rs1001179 and SOD2 rs4880 Variants and Risk for Multiple Sclerosis
AU - Elena García-Martín
AU - Javier Gómez-Tabales
AU - José A. G. Agúndez
AU - Julián Benito-León
AU - Jorge Millán-Pascual
AU - María Díaz-Sánchez
AU - Patricia Calleja
AU - Laura Turpín-Fenoll
AU - Hortensia Alonso-Navarro
AU - Esteban García-Albea
AU - Félix Javier Jiménez-Jiménez
PY - 2026
DA - 2026/10/01
JO - Biomolecules
DO - 10.3390/biom16101449
UR - https://www.mdpi.com/2218-273X/16/10/1449
AB - Objectives: Several lines of evidence point to a potential involvement of oxidative stress in the pathophysiology of multiple sclerosis (MS). Superoxide dismutase isoenzymes 1 and 2 (SOD1 and SOD2) and catalase (CAT) are key components of the enzymatic antioxidant defense system. Consequently, genetic variation in the genes encoding these enzymes may influence susceptibility to MS. However, previous studies examining the relationship between SOD1, SOD2, and CAT variants and MS susceptibility have yielded inconsistent findings. The present study aimed to investigate whether two common single-nucleotide variants (SNVs) in CAT and SOD2 are associated with MS risk in a Caucasian Spanish population. Methods: We investigated the CAT rs1001179 and SOD2 rs4880 variants in 300 patients with MS and 400 healthy controls using allele-specific TaqMan quantitative PCR assays. We further examined whether these variants were related to relevant clinical characteristics, including age at disease onset, disease severity, and clinical course/subtype. Results: Neither the genotype nor allele distributions of CAT rs1001179 and SOD2 rs4880 differed significantly between patients with MS and healthy controls. Furthermore, no significant relationships were observed between either variant and sex, age at disease onset, disease severity, or clinical MS subtype. Conclusions: The present study did not detect significant associations between the CAT rs1001179 or SOD2 rs4880 variants and MS susceptibility in the Caucasian Spanish population. Similarly, no significant associations were detected between these variants and the clinical characteristics evaluated. However, smaller genetic effects cannot be excluded.
SN - 2218-273X
ER -