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Peer-reviewedCC BY 4.0Frontiers in Endocrinology

Role of histone post-translational modifications in preeclampsia: from pathogenesis to diagnostic and therapeutic strategies

  • Yuanxuan Ma1,2
  • Renwei Zhang3
  • Mengting Yang1,2
  • Jingli Wang1,2
  • Bo Hou4
  • Shiguo Liu1,2
4 affiliations
  1. 1Prenatal Diagnosis Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China
  2. 2Department of Medical Genetics, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China
  3. 3Department of Laboratory, Peking University People’s Hospital Qingdao Hospital, Qingdao, Shandong, China
  4. 4Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China
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Abstract

Preeclampsia (PE) is a pregnancy-specific hypertensive disorder that poses a severe risk to maternal and fetal health. Owing to its incompletely elucidated pathogenesis, there is a lack of etiology-targeted therapeutic approaches in clinical practice, and pregnancy termination remains the primary intervention for PE. Emerging evidence indicates that histone post-translational modifications (HPTMs), a crucial class of epigenetic regulatory mechanisms, are extensively involved in the key pathological processes of PE by dynamically remodeling chromatin structures and regulating gene transcription. These processes include trophoblast dysfunction, placental vascular homeostasis dysregulation, immune-inflammatory disturbances, and endothelial dysfunction. In this review, we summarized the regulatory roles of HPTMs, such as methylation, acetylation, lactylation, citrullination, and ubiquitination, in PE pathogenesis. In addition, we discussed the potential and limitations of HPTMs and key modifying enzymes as candidate therapeutic targets and diagnostic biomarkers of PE. Overall, this review aims to summarize the reported roles of HPTMs in PE pathogenesis and examine promising diagnostic and therapeutic strategies from HPTMs perspective.

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Cite

BibTeXRIS
BibTeX
@article{ma2026role,
  title = {{Role of histone post-translational modifications in preeclampsia: from pathogenesis to diagnostic and therapeutic strategies}},
  author = {Yuanxuan Ma and Renwei Zhang and Mengting Yang and Jingli Wang and Bo Hou and Shiguo Liu},
  journal = {Frontiers in Endocrinology},
  year = {2026},
  month = oct,
  doi = {10.3389/fendo.2026.1973542},
  url = {https://doi.org/10.3389/fendo.2026.1973542},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Role of histone post-translational modifications in preeclampsia: from pathogenesis to diagnostic and therapeutic strategies
AU  - Yuanxuan Ma
AU  - Renwei Zhang
AU  - Mengting Yang
AU  - Jingli Wang
AU  - Bo Hou
AU  - Shiguo Liu
PY  - 2026
DA  - 2026/10/12
JO  - Frontiers in Endocrinology
DO  - 10.3389/fendo.2026.1973542
UR  - https://doi.org/10.3389/fendo.2026.1973542
AB  - Preeclampsia (PE) is a pregnancy-specific hypertensive disorder that poses a severe risk to maternal and fetal health. Owing to its incompletely elucidated pathogenesis, there is a lack of etiology-targeted therapeutic approaches in clinical practice, and pregnancy termination remains the primary intervention for PE. Emerging evidence indicates that histone post-translational modifications (HPTMs), a crucial class of epigenetic regulatory mechanisms, are extensively involved in the key pathological processes of PE by dynamically remodeling chromatin structures and regulating gene transcription. These processes include trophoblast dysfunction, placental vascular homeostasis dysregulation, immune-inflammatory disturbances, and endothelial dysfunction. In this review, we summarized the regulatory roles of HPTMs, such as methylation, acetylation, lactylation, citrullination, and ubiquitination, in PE pathogenesis. In addition, we discussed the potential and limitations of HPTMs and key modifying enzymes as candidate therapeutic targets and diagnostic biomarkers of PE. Overall, this review aims to summarize the reported roles of HPTMs in PE pathogenesis and examine promising diagnostic and therapeutic strategies from HPTMs perspective.
SN  - 1664-2392
ER  -