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Peer-reviewedCC BY-NC-NDActa pharmaceutica Sinica. B

Spatiotemporal crosstalk of post-translational modifications: A therapeutic avenue in spinal cord injury

  • Weishi Liang1
  • Chen Wang2
  • Yeqiu Xu1
  • Duan Sun1
  • Xinan Zhang2
  • Peng Yin1
  • Bo Han3
  • Xianjun Qu2
  • Yong Hai1
  1. 1Department of Orthopedic Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
  2. 2Joint Laboratory for Research & Treatment of Spinal Cord Injury in Spinal Deformity, Laboratory for Clinical Medicine, Capital Medical University, Beijing 100069, China
  3. 3Department of Spinal Surgery, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China
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Abstract

Spinal cord injury (SCI) triggers irreversible neurological dysfunction driven by sequential primary and secondary insults, with neuronal death and neuroinflammation as the central pathological determinants. Despite advances in neuroregeneration research, an incomplete understanding of the molecular regulators underlying these processes limits the development of effective SCI treatment strategies. Post-translational modifications (PTMs) function as critical “dynamic molecular switches” that spatiotemporally regulate protein function and signaling cascades, shaping the SCI microenvironment. Emerging evidence suggests that interdependent PTM networks—rather than isolated modifications—regulate the balance between deterioration and repair. This review synthesizes current insights into seven major PTMs implicated in neuronal death and neuroinflammation after SCI, emphasizing their cooperative crosstalk and the methodological challenges in decoding their temporal dynamics. We propose a “spatiotemporally regulated PTM network” framework to guide therapeutic interventions, highlighting multiplex PTM modulation as a promising strategy to enhance neuronal survival, reduce neuroinflammation, and promote functional recovery after SCI. This review deepens the understanding of PTM crosstalk in SCI pathology and provides new perspectives for developing novel PTM detection and clinical therapeutic strategies.

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Cite

BibTeXRIS
BibTeX
@article{liang2026spatiotemporal,
  title = {{Spatiotemporal crosstalk of post-translational modifications: A therapeutic avenue in spinal cord injury}},
  author = {Weishi Liang and Chen Wang and Yeqiu Xu and Duan Sun and Xinan Zhang and Peng Yin and Bo Han and Xianjun Qu and Yong Hai},
  journal = {Acta pharmaceutica Sinica. B},
  year = {2026},
  month = sep,
  doi = {10.1016/j.apsb.2026.08.032},
  url = {https://europepmc.org/article/PMC/PMC13729716},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Spatiotemporal crosstalk of post-translational modifications: A therapeutic avenue in spinal cord injury
AU  - Weishi Liang
AU  - Chen Wang
AU  - Yeqiu Xu
AU  - Duan Sun
AU  - Xinan Zhang
AU  - Peng Yin
AU  - Bo Han
AU  - Xianjun Qu
AU  - Yong Hai
PY  - 2026
DA  - 2026/09/02
JO  - Acta pharmaceutica Sinica. B
DO  - 10.1016/j.apsb.2026.08.032
UR  - https://europepmc.org/article/PMC/PMC13729716
AB  - Spinal cord injury (SCI) triggers irreversible neurological dysfunction driven by sequential primary and secondary insults, with neuronal death and neuroinflammation as the central pathological determinants. Despite advances in neuroregeneration research, an incomplete understanding of the molecular regulators underlying these processes limits the development of effective SCI treatment strategies. Post-translational modifications (PTMs) function as critical “dynamic molecular switches” that spatiotemporally regulate protein function and signaling cascades, shaping the SCI microenvironment. Emerging evidence suggests that interdependent PTM networks—rather than isolated modifications—regulate the balance between deterioration and repair. This review synthesizes current insights into seven major PTMs implicated in neuronal death and neuroinflammation after SCI, emphasizing their cooperative crosstalk and the methodological challenges in decoding their temporal dynamics. We propose a “spatiotemporally regulated PTM network” framework to guide therapeutic interventions, highlighting multiplex PTM modulation as a promising strategy to enhance neuronal survival, reduce neuroinflammation, and promote functional recovery after SCI. This review deepens the understanding of PTM crosstalk in SCI pathology and provides new perspectives for developing novel PTM detection and clinical therapeutic strategies.
SN  - 2211-3835
SN  - 2211-3843
ER  -