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Peer-reviewedCC BY 4.0Frontiers in Neurology

Shared mechanisms and therapeutic horizons: exploring the potential interplay between benign prostatic hyperplasia/lower urinary tract symptoms and Alzheimer’s disease

  • Min Song1
  • Anxu Liu2
  • Hao Liang3
  • Qingya Yang3
  • Bing Zhang3
  • Jie Cui4
  • Yue Qiu3
4 affiliations
  1. 1Department of Neurology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University
  2. 2Department of Clinical Medicine, Qingdao Medical College, Qingdao University
  3. 3Department of Urology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University
  4. 4School of Business and Management, Jilin University
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Abstract

Alzheimer’s disease (AD) and benign prostatic hyperplasia (BPH) are two prevalent age-related disorders with significant global healthcare burdens. Traditionally viewed as distinct conditions, emerging evidence suggests that they may share common pathophysiological mechanisms, including chronic inflammation, endocrine dysregulation, metabolic dysfunction, cardiovascular impairment, and sleep disturbances. This review synthesizes current epidemiological, mechanistic, and therapeutic insights linking BPH and AD, with a focus on their overlapping risk factors and molecular pathways. Although most of the currently available evidence is observational and cannot establish causality, understanding these interactions could inform novel preventive and therapeutic strategies to mitigate the dual burden of neurodegenerative and urological conditions in older populations.

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Cite

BibTeXRIS
BibTeX
@article{song2026shared,
  title = {{Shared mechanisms and therapeutic horizons: exploring the potential interplay between benign prostatic hyperplasia/lower urinary tract symptoms and Alzheimer’s disease}},
  author = {Min Song and Anxu Liu and Hao Liang and Qingya Yang and Bing Zhang and Jie Cui and Yue Qiu},
  journal = {Frontiers in Neurology},
  year = {2026},
  month = nov,
  doi = {10.3389/fneur.2026.1817059},
  url = {https://www.frontiersin.org/articles/10.3389/fneur.2026.1817059/full},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Shared mechanisms and therapeutic horizons: exploring the potential interplay between benign prostatic hyperplasia/lower urinary tract symptoms and Alzheimer’s disease
AU  - Min Song
AU  - Anxu Liu
AU  - Hao Liang
AU  - Qingya Yang
AU  - Bing Zhang
AU  - Jie Cui
AU  - Yue Qiu
PY  - 2026
DA  - 2026/11/05
JO  - Frontiers in Neurology
DO  - 10.3389/fneur.2026.1817059
UR  - https://www.frontiersin.org/articles/10.3389/fneur.2026.1817059/full
AB  - Alzheimer’s disease (AD) and benign prostatic hyperplasia (BPH) are two prevalent age-related disorders with significant global healthcare burdens. Traditionally viewed as distinct conditions, emerging evidence suggests that they may share common pathophysiological mechanisms, including chronic inflammation, endocrine dysregulation, metabolic dysfunction, cardiovascular impairment, and sleep disturbances. This review synthesizes current epidemiological, mechanistic, and therapeutic insights linking BPH and AD, with a focus on their overlapping risk factors and molecular pathways. Although most of the currently available evidence is observational and cannot establish causality, understanding these interactions could inform novel preventive and therapeutic strategies to mitigate the dual burden of neurodegenerative and urological conditions in older populations.
SN  - 1664-2295
ER  -