Skip to content
DraconiticResearch
Search Sources API
203,234 studies31 sourcesUpdated 49 min ago
Peer-reviewedCC BY 4.0Stem Cells International

Mechanisms of Neural Stem Cell Mediated Neurogenesis and Therapeutic Prospects Following Ischemic Stroke: A Review

  • Shuhong Wang1
  • Ji Zhang1
  • Peng Wang1
  • Peng Ye1
  • Jin Wu1
  • Lili Shi1
  • Xuheng Jiang1
  • Yuanlan Lu1
  • Hongfei Ge2
  • Anyong Yu1
  1. 1Department of Emergency Affiliated Hospital of Zunyi Medical University Zunyi Guizhou China zmchospital.com.cn
  2. 2Department of Neurosurgery Southwest Hospital Third Military Medical University (Army Medical University) Chongqing China tmmu.edu.cn
Read full textPDFDOICite

Abstract

Ischemic stroke is a refractory cerebrovascular disorder characterized by high incidence, disability, and mortality rates. Its core pathological features include extensive neuronal death within the ischemic zone and irreversible damage to neural circuits. Given the limited regenerative capacity of the central nervous system, regulating endogenous neurogenesis and reconstructing functional circuits are important strategies for treating neurological deficits. This narrative review summarizes the dynamic processes of activation, proliferation, migration, and differentiation of endogenous neural stem cells (NSCs) following ischemic stroke, and explores the therapeutic potential of exogenous NSC transplantation and its current applications. Distinct from existing reviews, this work systematically integrates neuroimmune crosstalk, metabolic reprogramming, and meningeal‑choroid‑plexus‑mediated niche regulation, further proposing a staged multimodal precision intervention framework. We also highlight critical confounding factors, including aging‑driven regenerative decline, and explicitly separate preclinical animal findings from limited human clinical evidence. Meanwhile, this review elucidates the core mechanisms through which neurogenesis mediates tissue repair and functional recovery in ischemic brain tissue. Furthermore, this review refines future research directions, such as spatiotemporally specific precision interventions and multimodal combination therapies, providing a systematic theoretical basis and research framework for developing novel NSC‐based therapeutic strategies for ischemic stroke.

Related

  1. Mitochondria as immunometabolic hubs in psoriasis: pathogenic mechanisms and therapeutic prospects
    Fangru Zhao, Yaoxing Guo, Xin Tong +5
    Frontiers in ImmunologyPeer-reviewedCC BY 4.0Full textImmunologyCrossrefDOAJEurope PMC
  2. Natural Products for Pancreatitis: Recent Advances, Molecular Mechanisms and Therapeutic Prospects
    Shiyan Su, Jing Yang, Meiyue Zhu +5
    CellsPeer-reviewedCC BY 4.0Cell biologyCrossref
  3. Inflammatory biomarkers and immune dysregulation in gestational diabetes mellitus: emerging mechanisms and therapeutic prospects
    Qian Zhang, Yang Shu, Yanan Gao
    Frontiers in ImmunologyPeer-reviewedCC BY 4.0ImmunologyFrontiersCrossref
  4. NLRP3 inflammasome and Sjögren disease: mechanisms, clinical associations and therapeutic prospects
    Rui Niu, Qiwei Li, Linwei Li +11
    Frontiers in ImmunologyPeer-reviewedCC BY 4.0ImmunologyCrossref
  5. Juvenile behavioral alterations and sex-dependent deficits in hippocampal neurogenesis following early-life stress in rats
    A. A. Colapietro, J. Grillo Balboa, K. M. Stefani +4
    bioRxivPreprintAll rights reservedFull textZoology & animal behaviourbioRxiv

Cite

BibTeXRIS
BibTeX
@article{wang2026mechanisms,
  title = {{Mechanisms of Neural Stem Cell Mediated Neurogenesis and Therapeutic Prospects Following Ischemic Stroke: A Review}},
  author = {Shuhong Wang and Ji Zhang and Peng Wang and Peng Ye and Jin Wu and Lili Shi and Xuheng Jiang and Yuanlan Lu and Hongfei Ge and Anyong Yu},
  journal = {Stem Cells International},
  year = {2026},
  month = oct,
  doi = {10.1155/sci/6934557},
  url = {https://doi.org/10.1155/sci/6934557},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Mechanisms of Neural Stem Cell Mediated Neurogenesis and Therapeutic Prospects Following Ischemic Stroke: A Review
AU  - Shuhong Wang
AU  - Ji Zhang
AU  - Peng Wang
AU  - Peng Ye
AU  - Jin Wu
AU  - Lili Shi
AU  - Xuheng Jiang
AU  - Yuanlan Lu
AU  - Hongfei Ge
AU  - Anyong Yu
PY  - 2026
DA  - 2026/10/26
JO  - Stem Cells International
DO  - 10.1155/sci/6934557
UR  - https://doi.org/10.1155/sci/6934557
AB  - Ischemic stroke is a refractory cerebrovascular disorder characterized by high incidence, disability, and mortality rates. Its core pathological features include extensive neuronal death within the ischemic zone and irreversible damage to neural circuits. Given the limited regenerative capacity of the central nervous system, regulating endogenous neurogenesis and reconstructing functional circuits are important strategies for treating neurological deficits. This narrative review summarizes the dynamic processes of activation, proliferation, migration, and differentiation of endogenous neural stem cells (NSCs) following ischemic stroke, and explores the therapeutic potential of exogenous NSC transplantation and its current applications. Distinct from existing reviews, this work systematically integrates neuroimmune crosstalk, metabolic reprogramming, and meningeal‑choroid‑plexus‑mediated niche regulation, further proposing a staged multimodal precision intervention framework. We also highlight critical confounding factors, including aging‑driven regenerative decline, and explicitly separate preclinical animal findings from limited human clinical evidence. Meanwhile, this review elucidates the core mechanisms through which neurogenesis mediates tissue repair and functional recovery in ischemic brain tissue. Furthermore, this review refines future research directions, such as spatiotemporally specific precision interventions and multimodal combination therapies, providing a systematic theoretical basis and research framework for developing novel NSC‐based therapeutic strategies for ischemic stroke.
SN  - 1687-966X
SN  - 1687-9678
ER  -