Natural Products for Pancreatitis: Recent Advances, Molecular Mechanisms and Therapeutic Prospects
- 1School of Basic Medicine, Kunming University of Science and Technology, Kunming 650500, China
- 2Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China
Abstract
Pancreatitis is a prevalent disorder of the digestive system, characterized by the rapid onset of pancreatic exudative edema and acinar cell necrosis. Clinically, the pathogenesis of pancreatitis is multifactorial and involves an intricate interplay among oxidative stress, dysregulated inflammatory signaling pathways, impaired autophagy, and aberrant apoptosis. Currently, no targeted disease-modifying pharmacotherapies are approved for clinical use in pancreatitis. In recent years, natural products have garnered increasing attention due to their inherent advantages, including chemical diversity, multi-target engagement, and favorable safety profiles, rendering them promising candidates for both preventive and therapeutic intervention in pancreatitis. Nevertheless, a comprehensive synthesis of current evidence regarding their mechanisms, bioactive constituents, and translational potential remains lacking. This review provides a rigorously categorized analysis of bioactive natural compounds (including alkaloids, quinones, terpenes, flavonoids, phenolics, and glycosides) and their molecular targets implicated in the prevention and treatment of pancreatitis. Furthermore, it critically evaluates emerging strategies for the rational engineering and optimization of plant-derived compounds, thereby offering a conceptual and mechanistic foundation for the development of novel therapeutics and innovative treatment paradigms for pancreatitis.
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BibTeX
@article{su2026natural,
title = {{Natural Products for Pancreatitis: Recent Advances, Molecular Mechanisms and Therapeutic Prospects}},
author = {Shiyan Su and Jing Yang and Meiyue Zhu and Yunhua Duan and Ruizhe He and Banglan Luo and Lei Tian and Ye Li},
journal = {Cells},
year = {2026},
month = nov,
doi = {10.3390/cells15212002},
url = {https://www.mdpi.com/2073-4409/15/21/2002},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Natural Products for Pancreatitis: Recent Advances, Molecular Mechanisms and Therapeutic Prospects
AU - Shiyan Su
AU - Jing Yang
AU - Meiyue Zhu
AU - Yunhua Duan
AU - Ruizhe He
AU - Banglan Luo
AU - Lei Tian
AU - Ye Li
PY - 2026
DA - 2026/11/03
JO - Cells
DO - 10.3390/cells15212002
UR - https://www.mdpi.com/2073-4409/15/21/2002
AB - Pancreatitis is a prevalent disorder of the digestive system, characterized by the rapid onset of pancreatic exudative edema and acinar cell necrosis. Clinically, the pathogenesis of pancreatitis is multifactorial and involves an intricate interplay among oxidative stress, dysregulated inflammatory signaling pathways, impaired autophagy, and aberrant apoptosis. Currently, no targeted disease-modifying pharmacotherapies are approved for clinical use in pancreatitis. In recent years, natural products have garnered increasing attention due to their inherent advantages, including chemical diversity, multi-target engagement, and favorable safety profiles, rendering them promising candidates for both preventive and therapeutic intervention in pancreatitis. Nevertheless, a comprehensive synthesis of current evidence regarding their mechanisms, bioactive constituents, and translational potential remains lacking. This review provides a rigorously categorized analysis of bioactive natural compounds (including alkaloids, quinones, terpenes, flavonoids, phenolics, and glycosides) and their molecular targets implicated in the prevention and treatment of pancreatitis. Furthermore, it critically evaluates emerging strategies for the rational engineering and optimization of plant-derived compounds, thereby offering a conceptual and mechanistic foundation for the development of novel therapeutics and innovative treatment paradigms for pancreatitis.
SN - 2073-4409
ER -