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Peer-reviewedCC BY-NC-NDCell communication and signaling : CCS

Circadian clock and its potential as a therapy for ischemic heart disease.

  • Yiran Wang1
  • He Wang1
  • Ning Liu1
  • Jiayi Zhang2
  • Bin Liu3
  1. 1Department of Cardiology, The Second Hospital of Jilin University, Changchun, 130021, P. R. China.
  2. 2Department of Hand Surgery, The First Hospital of Jilin University, Changchun, 130021, P. R. China.
  3. 3Department of Cardiology, The Second Hospital of Jilin University, Changchun, 130021, P. R. China. [email protected].
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Abstract

According to an epidemiological survey, myocardial infarction, ischemia-reperfusion injury, and aortic rupture usually occur in the morning and summer and are characterized by more severe symptoms and poorer prognosis. The occurrence, development, treatment difficulties, and poor prognosis of ischemic heart disease are closely related to circadian rhythm disorders and the abnormal transcription of circadian clock genes. Normal circadian rhythms regulate neurohumoral regulation and energy metabolism, thereby playing a protective or modulatory role in ischemic heart disease (IHD). HIF1α links the IHD and circadian signaling pathways through the hypoxia response element (HRE) and Per-Arnt-Sim (PAS) domains in gene promoters and enhancers.

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Cite

BibTeXRIS
BibTeX
@article{wang2026circadian,
  title = {{Circadian clock and its potential as a therapy for ischemic heart disease.}},
  author = {Yiran Wang and He Wang and Ning Liu and Jiayi Zhang and Bin Liu},
  journal = {Cell communication and signaling : CCS},
  year = {2026},
  month = jul,
  doi = {10.1186/s12964-026-03073-x},
  url = {https://europepmc.org/article/MED/42897642},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Circadian clock and its potential as a therapy for ischemic heart disease.
AU  - Yiran Wang
AU  - He Wang
AU  - Ning Liu
AU  - Jiayi Zhang
AU  - Bin Liu
PY  - 2026
DA  - 2026/07/01
JO  - Cell communication and signaling : CCS
DO  - 10.1186/s12964-026-03073-x
UR  - https://europepmc.org/article/MED/42897642
AB  - According to an epidemiological survey, myocardial infarction, ischemia-reperfusion injury, and aortic rupture usually occur in the morning and summer and are characterized by more severe symptoms and poorer prognosis. The occurrence, development, treatment difficulties, and poor prognosis of ischemic heart disease are closely related to circadian rhythm disorders and the abnormal transcription of circadian clock genes. Normal circadian rhythms regulate neurohumoral regulation and energy metabolism, thereby playing a protective or modulatory role in ischemic heart disease (IHD). HIF1α links the IHD and circadian signaling pathways through the hypoxia response element (HRE) and Per-Arnt-Sim (PAS) domains in gene promoters and enhancers.
SN  - 1478-811X
ER  -