Skip to content
DraconiticResearch
Search Sources API
197,768 studies31 sourcesUpdated 28 min ago
Peer-reviewedCC BYClocks & sleep

The Circadian Clock in Glioblastoma: Mechanisms and Therapeutic Potential.

  • Samaneh Ghorbani Shirkouhi1
  • Farzin Kamari2
  • Poul Flemming Høilund-Carlsen3,4
  • Morten Blaabjerg5,6
  • Abass Alavi7
  • Frantz Rom Poulsen8,9
  • Mona-Elisabeth R Revheim10,11
  • Anderson Matheus Pereira da Silva12
  • Sasan Andalib5,6
12 affiliations
  1. 1Independent Researcher, Rasht 4173143385, Iran.
  2. 2Department of Neurophysiology, Institute of Physiology, Eberhard Karls University of Tübingen, 72074 Tübingen, Germany.
  3. 3Department of Nuclear Medicine, Odense University Hospital, 5000 Odense, Denmark.
  4. 4Research Unit of Clinical Physiology and Nuclear Medicine, Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, 5230 Odense, Denmark.
  5. 5Research Unit of Neurology, Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, 5230 Odense, Denmark.
  6. 6Department of Neurology, Odense University Hospital, 5000 Odense, Denmark.
  7. 7Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  8. 8Department of Neurosurgery, Odense University Hospital, 5000 Odense, Denmark.
  9. 9Brain Research Interdisciplinary Guided Excellence (BRIDGE), University of Southern Denmark, 5230 Odense, Denmark.
  10. 10The Intervention Centre, Oslo University Hospital, 0372 Oslo, Norway.
  11. 11Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0372 Oslo, Norway.
  12. 12Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife 50670-420, PE, Brazil.
Read full textPDFDOICite

Abstract

Glioblastoma (GBM) is an aggressive brain cancer in adults. Circadian rhythms regulate the sleep-wake cycle, which influences the body's physiological functions. Disruption of circadian rhythms is associated with certain neurological diseases, including GBM. The present narrative review highlights the relationship between circadian rhythm and GBM, the related mechanisms, and the therapeutic approaches against GBM. It also discusses how alterations in the expression of core circadian genes contribute to glioma genesis, especially GBM, and how restoring normal circadian gene function may suppress GBM progression. Additionally, chronotherapy could be considered a potential therapeutic approach for GBM. Aligning chemotherapy and radiotherapy with the internal clock of each patient may have the potential to increase the efficacy of treatments. A better understanding of the potential mechanisms underlying the association between circadian rhythm and GBM pathogenesis may help guide future circadian-based therapeutic approaches; however, further investigation is required.

Related

  1. Circadian clock and its potential as a therapy for ischemic heart disease.
    Yiran Wang, He Wang, Ning Liu +2
    Cell communication and signaling : CCSPeer-reviewedCC BY-NC-NDFull textPhysiologyEurope PMCDOAJ
  2. Paired Transcriptomics of Glioblastoma Peripheral and Core Areas Reveals CNTN2 as a Potential Therapeutic Target
    Mathieu Larroquette, Katharina Sarnow, Miriam Meloni +14
    Cancer LettersPeer-reviewedLicence not statedGeneral biologyEpidemiology & public healthHAL
  3. Circadian rhythm dysregulation and ferroptosis in hypertension: mechanisms and therapeutic implications
    Hui Zeng, Jiawen Lin, Jun Chen
    Frontiers in Cardiovascular MedicinePeer-reviewedCC BY 4.0Full textPhysiologyCrossrefEurope PMCPMC
  4. Lactylation in glioblastoma: mechanisms and therapeutic perspectives
    Long Huang, Boyu Huang, Shizhen Kuang +1
    Frontiers in cell and developmental biologyPeer-reviewedCC BYFull textOncologyEurope PMCPMC
  5. Glioblastoma stem cell–immune microenvironment crosstalk: molecular mechanisms and therapeutic opportunities
    Chuanhai Xu, Linlin Chai, Wei Yuan
    Frontiers in ImmunologyPeer-reviewedCC BY 4.0Full textHuman geneticsCrossrefEurope PMC

Cite

BibTeXRIS
BibTeX
@article{shirkouhi2026circadian,
  title = {{The Circadian Clock in Glioblastoma: Mechanisms and Therapeutic Potential.}},
  author = {Samaneh Ghorbani Shirkouhi and Farzin Kamari and Poul Flemming Høilund-Carlsen and Morten Blaabjerg and Abass Alavi and Frantz Rom Poulsen and Mona-Elisabeth R Revheim and Anderson Matheus Pereira da Silva and Sasan Andalib},
  journal = {Clocks \& sleep},
  year = {2026},
  month = sep,
  doi = {10.3390/clockssleep8040059},
  url = {https://europepmc.org/article/MED/42924735},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - The Circadian Clock in Glioblastoma: Mechanisms and Therapeutic Potential.
AU  - Samaneh Ghorbani Shirkouhi
AU  - Farzin Kamari
AU  - Poul Flemming Høilund-Carlsen
AU  - Morten Blaabjerg
AU  - Abass Alavi
AU  - Frantz Rom Poulsen
AU  - Mona-Elisabeth R Revheim
AU  - Anderson Matheus Pereira da Silva
AU  - Sasan Andalib
PY  - 2026
DA  - 2026/09/24
JO  - Clocks & sleep
DO  - 10.3390/clockssleep8040059
UR  - https://europepmc.org/article/MED/42924735
AB  - Glioblastoma (GBM) is an aggressive brain cancer in adults. Circadian rhythms regulate the sleep-wake cycle, which influences the body's physiological functions. Disruption of circadian rhythms is associated with certain neurological diseases, including GBM. The present narrative review highlights the relationship between circadian rhythm and GBM, the related mechanisms, and the therapeutic approaches against GBM. It also discusses how alterations in the expression of core circadian genes contribute to glioma genesis, especially GBM, and how restoring normal circadian gene function may suppress GBM progression. Additionally, chronotherapy could be considered a potential therapeutic approach for GBM. Aligning chemotherapy and radiotherapy with the internal clock of each patient may have the potential to increase the efficacy of treatments. A better understanding of the potential mechanisms underlying the association between circadian rhythm and GBM pathogenesis may help guide future circadian-based therapeutic approaches; however, further investigation is required.
SN  - 2624-5175
ER  -