Synergistically reinforced bioresorbable hydrogel for mechanical–biological decoupling and osteogenic–angiogenic coupling
- 1Department of Stomatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, PR China
- 2Department of Biobased Materials Science, Kyoto Institute of Technology, Matsugasaki, Kyoto, 606-8585, Japan
Abstract
Ideal hydrogels for craniofacial bone regeneration should combine mechanical robustness, tunable bioresorption, and synergistic osteogenic–angiogenic bioactivity. However, conventional hydrogels suffer from an inherent trade-off between mechanical performance and biological activity, since both properties are dominated by crosslinking density. Here, a synergistically reinforced bioresorbable hydrogel system is developed by integrating highly ordered melt electrowriting poly(lactic-co-glycolic acid) (PLGA) microfibrous scaffolds with bioactive glass (BG)-reinforced and functionalized gelatin methacryloyl (GelMA) matrix. This architectural reinforcement provides a strategy for partial mechanical–biological decoupling, enabling mechanical properties to be tailored independently of hydrogel crosslinking while preserving the bioactivity of the GelMA phase. The composite hydrogel efficiently promotes osteogenic differentiation of rat bone marrow mesenchymal stem cells and enhances angiogenic activities of human umbilical vein endothelial cells. The enrichment of Ras/MAPK signaling suggests a potential bifunctional role of this pathway in osteogenic and angiogenic regulation. In a rat critical-sized calvarial defect model, the scaffold remarkably induces extensive vascularized bone regeneration, achieving a bone volume fraction of 59.9 ± 7.4% at 12 weeks post-implantation. This work establishes a synergistic reinforcement strategy that decouples mechanical and biological functions while orchestrating osteogenic–angiogenic coupling for craniofacial bone regeneration.
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BibTeX
@article{hong2026synergistically,
title = {{Synergistically reinforced bioresorbable hydrogel for mechanical–biological decoupling and osteogenic–angiogenic coupling}},
author = {Yue Hong and Huali Lu and Jie Luo and Yaoyi Li and Yizi Ye and Yuning Hua and Huaizhong Xu and Ting Xu},
journal = {Materials Today Bio},
year = {2026},
month = oct,
doi = {10.1016/j.mtbio.2026.103736},
url = {https://doi.org/10.1016/j.mtbio.2026.103736},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Synergistically reinforced bioresorbable hydrogel for mechanical–biological decoupling and osteogenic–angiogenic coupling
AU - Yue Hong
AU - Huali Lu
AU - Jie Luo
AU - Yaoyi Li
AU - Yizi Ye
AU - Yuning Hua
AU - Huaizhong Xu
AU - Ting Xu
PY - 2026
DA - 2026/10/13
JO - Materials Today Bio
DO - 10.1016/j.mtbio.2026.103736
UR - https://doi.org/10.1016/j.mtbio.2026.103736
AB - Ideal hydrogels for craniofacial bone regeneration should combine mechanical robustness, tunable bioresorption, and synergistic osteogenic–angiogenic bioactivity. However, conventional hydrogels suffer from an inherent trade-off between mechanical performance and biological activity, since both properties are dominated by crosslinking density. Here, a synergistically reinforced bioresorbable hydrogel system is developed by integrating highly ordered melt electrowriting poly(lactic-co-glycolic acid) (PLGA) microfibrous scaffolds with bioactive glass (BG)-reinforced and functionalized gelatin methacryloyl (GelMA) matrix. This architectural reinforcement provides a strategy for partial mechanical–biological decoupling, enabling mechanical properties to be tailored independently of hydrogel crosslinking while preserving the bioactivity of the GelMA phase. The composite hydrogel efficiently promotes osteogenic differentiation of rat bone marrow mesenchymal stem cells and enhances angiogenic activities of human umbilical vein endothelial cells. The enrichment of Ras/MAPK signaling suggests a potential bifunctional role of this pathway in osteogenic and angiogenic regulation. In a rat critical-sized calvarial defect model, the scaffold remarkably induces extensive vascularized bone regeneration, achieving a bone volume fraction of 59.9 ± 7.4% at 12 weeks post-implantation. This work establishes a synergistic reinforcement strategy that decouples mechanical and biological functions while orchestrating osteogenic–angiogenic coupling for craniofacial bone regeneration.
SN - 2590-0064
ER -