Histological characterization of major internal organs in infant common marmosets (Callithrix jacchus)
5 affiliations
- 1College of Veterinary Medicine, Department of Laboratory Animal Medicine, Seoul National University, Seoul, Republic of Korea
- 2Department of Experiment Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
- 3Seoul National University Hospital Marmoset Model Resource Bank (SNUH-MMRB), Seoul, Republic of Korea
- 4Department of Veterinary Pathology and Research Institute of Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea
- 5Graduate School of Translational Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
Abstract
The common marmoset (Callithrix jacchus) is a widely used nonhuman primate model in biomedical research. However, access to infant tissues is limited, and descriptive histological information for early postnatal organ development is needed. We examined a qualitative, descriptive histological overview of five major organs (liver, kidney, spleen, lung and heart) in infant (0–3 weeks) and adult (>12 months) marmosets using hematoxylin and eosin, Ki67 immunohistochemistry, Alcian blue–periodic acid–Schiff, and Sirius red staining. The examined infant livers showed multilayered hepatocyte cords, higher nuclear-to-cytoplasmic ratios, and extramedullary hematopoiesis, and the adult livers exhibited organized hepatic plates and mature stromal structures. The infant kidneys demonstrated active nephrogenesis with immature nephrons, showing progressively more mature glomerular morphology in adults. The spleen displayed small and poorly developed white pulp in infants but fewer, larger, and distinct white pulp structures in adults. The lungs showed thick interalveolarsepta and irregular airspaces during the early postnatal stages, with progressive septal thinning and expanded airspaces in maturity. The infant hearts exhibited loosely packed cardiomyocytes and developing valves, with the adult hearts showing hypertrophied, striated myocardium and compact collagenous valve structures. This study provides descriptive histological information for interpreting developmental features in infant marmosets and supports the use of these data in developmental primate pathology.
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BibTeX
@article{kim2026histological,
title = {{Histological characterization of major internal organs in infant common marmosets (Callithrix jacchus)}},
author = {Hyeon Ah Kim and Na-Young Lee and Jina Kwak and Hee Jin Choi and Gyeong Min Yoon and Sang Hyeok Seok and Yu Jin Lee and Na Yun Lee and Dae-Yong Kim and Jun Won Park and Byeong-Cheol Kang},
journal = {PLOS One},
year = {2026},
month = sep,
doi = {10.1371/journal.pone.0357273},
url = {https://doi.org/10.1371/journal.pone.0357273},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Histological characterization of major internal organs in infant common marmosets (Callithrix jacchus)
AU - Hyeon Ah Kim
AU - Na-Young Lee
AU - Jina Kwak
AU - Hee Jin Choi
AU - Gyeong Min Yoon
AU - Sang Hyeok Seok
AU - Yu Jin Lee
AU - Na Yun Lee
AU - Dae-Yong Kim
AU - Jun Won Park
AU - Byeong-Cheol Kang
PY - 2026
DA - 2026/09/02
JO - PLOS One
DO - 10.1371/journal.pone.0357273
UR - https://doi.org/10.1371/journal.pone.0357273
AB - The common marmoset (Callithrix jacchus) is a widely used nonhuman primate model in biomedical research. However, access to infant tissues is limited, and descriptive histological information for early postnatal organ development is needed. We examined a qualitative, descriptive histological overview of five major organs (liver, kidney, spleen, lung and heart) in infant (0–3 weeks) and adult (>12 months) marmosets using hematoxylin and eosin, Ki67 immunohistochemistry, Alcian blue–periodic acid–Schiff, and Sirius red staining. The examined infant livers showed multilayered hepatocyte cords, higher nuclear-to-cytoplasmic ratios, and extramedullary hematopoiesis, and the adult livers exhibited organized hepatic plates and mature stromal structures. The infant kidneys demonstrated active nephrogenesis with immature nephrons, showing progressively more mature glomerular morphology in adults. The spleen displayed small and poorly developed white pulp in infants but fewer, larger, and distinct white pulp structures in adults. The lungs showed thick interalveolarsepta and irregular airspaces during the early postnatal stages, with progressive septal thinning and expanded airspaces in maturity. The infant hearts exhibited loosely packed cardiomyocytes and developing valves, with the adult hearts showing hypertrophied, striated myocardium and compact collagenous valve structures. This study provides descriptive histological information for interpreting developmental features in infant marmosets and supports the use of these data in developmental primate pathology.
SN - 1932-6203
ER -