Conserved Molecular Markers for Tectorecipient Subdivisions of the Visual Thalamus in Mice and Tree Shrews
Abstract
Sensory systems share common circuit organization motifs across mammalian species; however, anatomical subdivisions show varying degrees of complexity depending on ecological niche and species-specific sensory requirements. While neuroanatomical connections seem preserved within the visual system, it remains unknown if molecularly defined cell-types share a similar degree of conservation, regarding not only their functional properties but also connectivity. Here we analyze the organization, molecular marker expression, and connections between two prominent visual centers, the superior colliculus (SC) and the dorsal lateral geniculate nucleus of the thalamus (dLGN), in the mouse and the tree shrew, a highly visual, diurnal species closely related to primates. Previous attempts to link molecular markers to subdivisions and connectivity of the dLGN have shown lack of conservation across species, thus preventing the systematic investigation of brain-wide interactions involved in vision. Leveraging recent single-cell and single-nucleus RNA sequencing studies, our results unravel a conserved molecular marker that shows spatial restriction in the dLGN and correlates with the location of connections from the SC in both the mouse and the tree shrew of either sex. We extend our findings by confirming the presence of this molecular marker in the human dLGN. These results provide a molecular definition and genetic access point for subdivisions of the dLGN in the mouse and tree shrew, enabling cell-type specific studies of the parallel processing of visual information.
Related
- Distinct In Vivo Electrophysiological Profiles of Mediodorsal Thalamus Subdivisions
- An integrated multi-omic atlas of the choroid plexus highlights conserved molecular programs of epithelial function
- Sequence-aware genotyping improves the accuracy of molecular markers associated with cassava mosaic disease resistance loci
- An unexploited almond biodiversity in central Italy: Genetic characterization and conservation strategies using molecular markers
- Past, present, and future of SSR molecular markers in bee studies
BibTeX
@article{oliver2026conserved,
title = {{Conserved Molecular Markers for Tectorecipient Subdivisions of the Visual Thalamus in Mice and Tree Shrews}},
author = {Nicholas M. Oliver and Maia Jin Classe and Sebastian Werneburg and Elise L. Savier},
journal = {eneuro},
year = {2026},
month = oct,
doi = {10.1523/eneuro.0313-26.2026},
url = {https://www.eneuro.org/lookup/doi/10.1523/ENEURO.0313-26.2026},
note = {CC BY-NC-SA 4.0},
}
RIS
TY - JOUR
TI - Conserved Molecular Markers for Tectorecipient Subdivisions of the Visual Thalamus in Mice and Tree Shrews
AU - Nicholas M. Oliver
AU - Maia Jin Classe
AU - Sebastian Werneburg
AU - Elise L. Savier
PY - 2026
DA - 2026/10/22
JO - eneuro
DO - 10.1523/eneuro.0313-26.2026
UR - https://www.eneuro.org/lookup/doi/10.1523/ENEURO.0313-26.2026
AB - Sensory systems share common circuit organization motifs across mammalian species; however, anatomical subdivisions show varying degrees of complexity depending on ecological niche and species-specific sensory requirements. While neuroanatomical connections seem preserved within the visual system, it remains unknown if molecularly defined cell-types share a similar degree of conservation, regarding not only their functional properties but also connectivity. Here we analyze the organization, molecular marker expression, and connections between two prominent visual centers, the superior colliculus (SC) and the dorsal lateral geniculate nucleus of the thalamus (dLGN), in the mouse and the tree shrew, a highly visual, diurnal species closely related to primates. Previous attempts to link molecular markers to subdivisions and connectivity of the dLGN have shown lack of conservation across species, thus preventing the systematic investigation of brain-wide interactions involved in vision. Leveraging recent single-cell and single-nucleus RNA sequencing studies, our results unravel a conserved molecular marker that shows spatial restriction in the dLGN and correlates with the location of connections from the SC in both the mouse and the tree shrew of either sex. We extend our findings by confirming the presence of this molecular marker in the human dLGN. These results provide a molecular definition and genetic access point for subdivisions of the dLGN in the mouse and tree shrew, enabling cell-type specific studies of the parallel processing of visual information.
SN - 2373-2822
ER -