Quantitative Changes in Iris Vessel Area Density During Valsalva Maneuver in Healthy Eyes.
5 affiliations
- 1School of Health Science and Engineering, University of Shanghai for Science & Technology, Shanghai, People's Republic of China.
- 2Eye Institute, Eye and Ear, Nose, and Throat Hospital, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
- 3NHC Key Laboratory of Myopia (Fudan University), Shanghai, People's Republic of China.
- 4Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, People's Republic of China.
- 5Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, People's Republic of China.
Abstract
Purpose
To quantify changes in iris vessel area density (VAD) during the Valsalva maneuver (VM) and explore their associations with anterior segment parameters in healthy subjects.Methods
This prospective cross-sectional study included 82 healthy volunteers, with one eye randomly selected for analysis. Iris VAD was quantified at baseline and during VM using optical coherence tomography angiography. Anterior segment parameters and intraocular pressure (IOP) were also assessed under both conditions.Results
Compared to baseline, significant reductions in total iris VAD were observed during VM (P = 0.029), with more pronounced decreases in the inner and outer iris regions (both P < 0.010). Concurrently, VM led to a significant elevation in IOP (P < 0.001), reductions in anterior chamber depth (P = 0.020) and volume (P < 0.001), and an increase in crystalline lens rise (P = 0.004). During VM, smaller values were observed in scleral spur angle (SSA500, P = 0.006; SSA750, P = 0.002), angle opening distance (AOD500, P = 0.014; AOD750, P = 0.001), anterior chamber angle (ACA750, P = 0.013), and trabecular-iris space area (TISA750, P = 0.004). Regression analysis revealed that axial length (AL), changes in TISA750, and changes in lens thickness were associated with VM-induced iris VAD changes (all P < 0.05).Conclusions
VM reduced iris microcirculation in healthy individuals, particularly in those with shorter AL, accompanied by structural anterior segment changes.Translational relevance
This study provides microvascular evidence of VM-induced iris hypoperfusion and suggests that hemodynamic mechanisms contribute to anterior segment alterations during VM.
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BibTeX
@article{shi2026quantitative,
title = {{Quantitative Changes in Iris Vessel Area Density During Valsalva Maneuver in Healthy Eyes.}},
author = {Yuanfang Shi and Yanwen Fang and Yating Tang and Yi Lu and Xiangjia Zhu and Yinglei Zhang},
journal = {Translational vision science \& technology},
year = {2026},
month = oct,
doi = {10.1167/tvst.15.10.4},
url = {https://europepmc.org/article/MED/42831731},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Quantitative Changes in Iris Vessel Area Density During Valsalva Maneuver in Healthy Eyes.
AU - Yuanfang Shi
AU - Yanwen Fang
AU - Yating Tang
AU - Yi Lu
AU - Xiangjia Zhu
AU - Yinglei Zhang
PY - 2026
DA - 2026/10/01
JO - Translational vision science & technology
DO - 10.1167/tvst.15.10.4
UR - https://europepmc.org/article/MED/42831731
AB - Purpose To quantify changes in iris vessel area density (VAD) during the Valsalva maneuver (VM) and explore their associations with anterior segment parameters in healthy subjects.Methods This prospective cross-sectional study included 82 healthy volunteers, with one eye randomly selected for analysis. Iris VAD was quantified at baseline and during VM using optical coherence tomography angiography. Anterior segment parameters and intraocular pressure (IOP) were also assessed under both conditions.Results Compared to baseline, significant reductions in total iris VAD were observed during VM (P = 0.029), with more pronounced decreases in the inner and outer iris regions (both P < 0.010). Concurrently, VM led to a significant elevation in IOP (P < 0.001), reductions in anterior chamber depth (P = 0.020) and volume (P < 0.001), and an increase in crystalline lens rise (P = 0.004). During VM, smaller values were observed in scleral spur angle (SSA500, P = 0.006; SSA750, P = 0.002), angle opening distance (AOD500, P = 0.014; AOD750, P = 0.001), anterior chamber angle (ACA750, P = 0.013), and trabecular-iris space area (TISA750, P = 0.004). Regression analysis revealed that axial length (AL), changes in TISA750, and changes in lens thickness were associated with VM-induced iris VAD changes (all P < 0.05).Conclusions VM reduced iris microcirculation in healthy individuals, particularly in those with shorter AL, accompanied by structural anterior segment changes.Translational relevance This study provides microvascular evidence of VM-induced iris hypoperfusion and suggests that hemodynamic mechanisms contribute to anterior segment alterations during VM.
SN - 2164-2591
ER -