All‐Amyloid Functional Coacervates
- 1Nanomaterials and Polymer Nanocomposites Laboratory School of Engineering University of British Columbia Kelowna BC Canada
- 2Department of Health Sciences and Technology ETH Zürich Zürich Switzerland
- 3Department of Materials ETH Zürich Zürich Switzerland
Abstract
Electrostatic complex coacervates offer a robust pathway to convert homogeneous oppositely charged polyelectrolyte solutions into condensed structured liquids via liquid–liquid phase separation (LLPS). Directing these principles toward artificial, all‐proteinaceous complex coacervates enables the development of soft matter systems fully compatible with a broad range of advanced biotechnological products. Here, we employ charge‐tunable β‐lactoglobulin and lysozyme amyloid nanofibrils as building blocks toward fully proteinaceous functional materials. The functionality is dictated by engineering the composition and self‐organization of oppositely charged amyloid nanofibrils at the liquid–liquid interface. Depending on the path and process followed, we demonstrate all‐amyloid interfacial complex coacervates in the form of vein‐like tubular structures or capsules with tunable electrical or ionic conductivity, viscoelasticity, multidimensional morphology, and programmable macromolecular crowding. These constructs, made solely of amyloid constituents, provide a general platform for artificial protein scaffolds and advanced materials with potential applications in bioelectronics and bio‐optics.
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BibTeX
@article{hashemi2026allamyloid,
title = {{All‐Amyloid Functional Coacervates}},
author = {Seyyed Alireza Hashemi and Mohammad Peydayesh and Laura Baraldi and Mohammad Arjmand and Raffaele Mezzenga},
journal = {Advanced Materials (Deerfield Beach, Fla.)},
year = {2026},
month = aug,
doi = {10.1002/adma.74737},
url = {https://doi.org/10.1002/adma.74737},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - All‐Amyloid Functional Coacervates
AU - Seyyed Alireza Hashemi
AU - Mohammad Peydayesh
AU - Laura Baraldi
AU - Mohammad Arjmand
AU - Raffaele Mezzenga
PY - 2026
DA - 2026/08/24
JO - Advanced Materials (Deerfield Beach, Fla.)
DO - 10.1002/adma.74737
UR - https://doi.org/10.1002/adma.74737
AB - Electrostatic complex coacervates offer a robust pathway to convert homogeneous oppositely charged polyelectrolyte solutions into condensed structured liquids via liquid–liquid phase separation (LLPS). Directing these principles toward artificial, all‐proteinaceous complex coacervates enables the development of soft matter systems fully compatible with a broad range of advanced biotechnological products. Here, we employ charge‐tunable β‐lactoglobulin and lysozyme amyloid nanofibrils as building blocks toward fully proteinaceous functional materials. The functionality is dictated by engineering the composition and self‐organization of oppositely charged amyloid nanofibrils at the liquid–liquid interface. Depending on the path and process followed, we demonstrate all‐amyloid interfacial complex coacervates in the form of vein‐like tubular structures or capsules with tunable electrical or ionic conductivity, viscoelasticity, multidimensional morphology, and programmable macromolecular crowding. These constructs, made solely of amyloid constituents, provide a general platform for artificial protein scaffolds and advanced materials with potential applications in bioelectronics and bio‐optics.
SN - 0935-9648
SN - 1521-4095
ER -