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Peer-reviewedCC BY 4.0Small Science

Rational Design of Glycolipid‐Based Coacervates for Sequestration of Macromolecules and Enveloped Viruses

  • Nikesh Dewangan1
  • Sandeep Yadav2
  • Sarani Biswas1
  • Indrani Das Jana3
  • Ananya Ghosh1
  • Priyaraj Pal1
  • Arindam Mondal3
  • Amirul Islam Mallick2
  • Pradip Kumar Tarafdar1
  1. 1Department of Chemical Sciences Indian Institute of Science Education and Research Kolkata Mohanpur India
  2. 2Department of Biological Sciences Indian Institute of Science Education and Research Kolkata Mohanpur India
  3. 3Department of Bioscience and Biotechnology Indian Institute of Technology Kharagpur Kharagpur India
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Abstract

Molecular self‐assembly offers a powerful route to engineer sophisticated materials that mimic biological compartmentalization. Inspired by liquid–liquid phase separation (LLPS), which drives the formation of cellular membraneless organelles, we rationally designed glycolipid‐based coacervates by tuning the attractive and repulsive intermolecular interactions. The low‐molecular‐weight glycolipid‐based polyanionic amphiphiles self‐assemble into stable coacervate droplets in an aqueous medium at low micromolar concentrations. The glycolipid‐based self‐coacervates demonstrate the ability to sequester dyes, drug‐like molecules, proteins, and microorganisms, including influenza and lentiviruses. During the sequestration, the coacervates appear to mask the viral surface proteins, blocking viral attachment to host cell receptors and thereby preventing viral entry into host cells.

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Cite

BibTeXRIS
BibTeX
@article{dewangan2026rational,
  title = {{Rational Design of Glycolipid‐Based Coacervates for Sequestration of Macromolecules and Enveloped Viruses}},
  author = {Nikesh Dewangan and Sandeep Yadav and Sarani Biswas and Indrani Das Jana and Ananya Ghosh and Priyaraj Pal and Arindam Mondal and Amirul Islam Mallick and Pradip Kumar Tarafdar},
  journal = {Small Science},
  year = {2026},
  month = oct,
  doi = {10.1002/smsc.70399},
  url = {https://doi.org/10.1002/smsc.70399},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Rational Design of Glycolipid‐Based Coacervates for Sequestration of Macromolecules and Enveloped Viruses
AU  - Nikesh Dewangan
AU  - Sandeep Yadav
AU  - Sarani Biswas
AU  - Indrani Das Jana
AU  - Ananya Ghosh
AU  - Priyaraj Pal
AU  - Arindam Mondal
AU  - Amirul Islam Mallick
AU  - Pradip Kumar Tarafdar
PY  - 2026
DA  - 2026/10/25
JO  - Small Science
DO  - 10.1002/smsc.70399
UR  - https://doi.org/10.1002/smsc.70399
AB  - Molecular self‐assembly offers a powerful route to engineer sophisticated materials that mimic biological compartmentalization. Inspired by liquid–liquid phase separation (LLPS), which drives the formation of cellular membraneless organelles, we rationally designed glycolipid‐based coacervates by tuning the attractive and repulsive intermolecular interactions. The low‐molecular‐weight glycolipid‐based polyanionic amphiphiles self‐assemble into stable coacervate droplets in an aqueous medium at low micromolar concentrations. The glycolipid‐based self‐coacervates demonstrate the ability to sequester dyes, drug‐like molecules, proteins, and microorganisms, including influenza and lentiviruses. During the sequestration, the coacervates appear to mask the viral surface proteins, blocking viral attachment to host cell receptors and thereby preventing viral entry into host cells.
SN  - 2688-4046
ER  -