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Peer-reviewedCC BYJournal for ImmunoTherapy of Cancer

249 A genome-scale, in vivo transcription factor screen identifies a previously unrecognized factor that enhances CAR-T persistence and tumor control under high-dose rechallenge

  • Yuan Liu1
  • Hao Wang2
  • Qi Zhang3
  • Yixuan Zhou4
  • Xiaoyu Zhou5
  • Peng Zhang1
  • Lina Zhou6
  • Jiabiao Hu1
  • Aijun Ti1
  • Tianying Chen1
  • Xu Feng1
  • George Church7
1 more authors
  • Luhan Yang1
7 affiliations
  1. 1Qihan Biotechnology, Hangzhou, Zhejiang, China
  2. 2Chinese PLA General Hospital, Beijing, China
  3. 3Department of Nursing, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
  4. 4Department of Clinical Laboratory, Zhejiang University School of Medicine Sir Run Run Shaw Hospital, Hangzhou, Zhejiang, China
  5. 5Shanghai Tenth People’s Hospital, Shanghai, China
  6. 6Department of Clinical Data Research, Chongqing Emergency Medical Center; Chongqing University Central Hospital, Chongqing University, Chongqing, China
  7. 7Department of Genetics, Harvard Medical School, Boston, MA, USA
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Cite

BibTeXRIS
BibTeX
@article{liu2026genomescale,
  title = {{249 A genome-scale, in vivo transcription factor screen identifies a previously unrecognized factor that enhances CAR-T persistence and tumor control under high-dose rechallenge}},
  author = {Yuan Liu and Hao Wang and Qi Zhang and Yixuan Zhou and Xiaoyu Zhou and Peng Zhang and Lina Zhou and Jiabiao Hu and Aijun Ti and Tianying Chen and Xu Feng and George Church and Luhan Yang},
  journal = {Journal for ImmunoTherapy of Cancer},
  year = {2026},
  month = nov,
  doi = {10.1136/jitc-2026-sitc2026.0249},
  url = {https://doi.org/10.1136/jitc-2026-sitc2026.0249},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - 249 A genome-scale, in vivo transcription factor screen identifies a previously unrecognized factor that enhances CAR-T persistence and tumor control under high-dose rechallenge
AU  - Yuan Liu
AU  - Hao Wang
AU  - Qi Zhang
AU  - Yixuan Zhou
AU  - Xiaoyu Zhou
AU  - Peng Zhang
AU  - Lina Zhou
AU  - Jiabiao Hu
AU  - Aijun Ti
AU  - Tianying Chen
AU  - Xu Feng
AU  - George Church
AU  - Luhan Yang
PY  - 2026
DA  - 2026/11/06
JO  - Journal for ImmunoTherapy of Cancer
DO  - 10.1136/jitc-2026-sitc2026.0249
UR  - https://doi.org/10.1136/jitc-2026-sitc2026.0249
SN  - 2051-1426
ER  -